Artículo
Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer
Valtorta, Silvia Elsa
; Scaglione, María Cristina; Acosta, P.; Coronel, J. E.; Beldomenico, Horacio Ramon; Boggio, Juan Carlos
Fecha de publicación:
09/2005
Editorial:
Springer
Revista:
International Journal Of Biometeorology
ISSN:
0020-7128
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The objective was to investigate circadian variations of blood and milk lead toxicokinetics in dairy cows in summer. Twenty lactating Holstein animals were randomly assigned to 4 treatments, corresponding to different hours after onset of light (HALO): 2, 8, 14 and 20. Cows received a single intravenous administration of 2.5 mg/kg lead as lead acetate. Blood and milk samples were taken and analyzed by atomic absorption spectrophotometry. For each toxicokinetic parameter, a one-way analysis of variance was performed to outline the existence of daily variations. Significant blood differences as a function of HALO were found for the hybrid constant of distribution (á), hybrid constant of elimination (â), elimination half-life (t1=2_ ), area under the curve (AUC), volume of distribution at steady state (Vss) and clearance (ClB) (p<0.05). Half-life of elimination presented two peaks at 2 and 14 HALO. Milk data showed significant differences for maximum concentration and AUC (p<0.05). The ratio AUCmilk/ AUCblood was utilized to estimate penetration of lead in milk. It differed significantly along the day (p<0.05). Milk data for the significant parameters could be fitted to circadian rhythms. No circadian rhythms were detected in blood parameters or in the ratio AUCmilk/AUCblood.
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Valtorta, Silvia Elsa; Scaglione, María Cristina; Acosta, P.; Coronel, J. E.; Beldomenico, Horacio Ramon; et al.; Daily rhythms in blood and milk lead toxicokinetics following intravenous administration of lead acetate to dairy cows in summer; Springer; International Journal Of Biometeorology; 50; 3; 9-2005; 133-138
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