Artículo
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
Aulicino, Paula
; Gómez Carrillo, Manuel
; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes
; Carr, Jean; Sen, Luisa
; Foley, Brian
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Fecha de publicación:
03/2012
Editorial:
Elsevier Science
Revista:
Infection, Genetics and Evolution
ISSN:
1567-1348
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; et al.; Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains; Elsevier Science; Infection, Genetics and Evolution; 12; 2; 3-2012; 443-447
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