Artículo
Sphinganine/sphingosine (SA/SO) ratio and intake of fumonisin contamianted tortillas in a Mexican population
Landeros, Patricia; Reyes, Waldina; Torres, Adriana Mabel
; Rojo, Federico Gabriel Antonio
; Chulze, Sofia Noemi
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Fecha de publicación:
12/2005
Editorial:
Asociación Toxicológica Argentina
Revista:
Acta Toxicológica Argentina
ISSN:
0327-9286
e-ISSN:
1851-3743
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The fumonisins are mycotoxins relevant due to their toxicological effects on animals and humans. Based on the current knowledge of the mechanism of action of fumonisins, the sphinganine/sphingosine (Sa/So) ratio is a valid biomarker of exposure in animal studies and could also be useful in human studies if the ratio correlate with fumonisin intake. The Sa/So ratio was evaluated in a Mexican population at three stages of maize based food (tortillas) consumption. A Sa/So ratio higher than 1 was found at the A (regular consumption) and C (re-assumption of the regular consumption) stages, while during the B (stopping of the tortillas consumption for two weeks) stage the Sa/So ratio was lower than 1. This report showed that there is an association between the intake of fumonisin contaminated maize based foods and the elevation of the Sa/So ratio in human samples. Mexican population is exposed with a continuous high consumption of maize based foods commonly contaminated with fumonisins.
Palabras clave:
Sphinganine/sphingosine
,
Tortillas
,
Mexican population
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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Landeros, Patricia; Reyes, Waldina; Torres, Adriana Mabel; Rojo, Federico Gabriel Antonio; Chulze, Sofia Noemi; Sphinganine/sphingosine (SA/SO) ratio and intake of fumonisin contamianted tortillas in a Mexican population; Asociación Toxicológica Argentina; Acta Toxicológica Argentina; 13; 2; 12-2005; 8-11
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