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dc.contributor.author
Veuthey, Tania Vanesa
dc.contributor.author
Burkovski, Andras
dc.date.available
2024-07-16T13:44:06Z
dc.date.issued
2023
dc.identifier.citation
Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases; 24th International C. elegans Conference; Glasgow; Reino Unido; 2023; 392-392
dc.identifier.uri
http://hdl.handle.net/11336/240063
dc.description.abstract
As life expectancy increase, age-related disorders, such us neurodegenerative diseases (ND), have become more prevalent. Moreover, treatments only attenuate some symptoms, but fail to arrest characteristic neuronal proteotoxicity. Thus, new challenges emerge to science in order to understand molecular basis of these disorders. Lately, the gut-brain axis has gain attention and a close relation between gut microorganism and ND has been proposed. The aim of our work was to evaluate the relevance of the microbiota in the progression of proteotoxic-based disorders, assessing the impact of six non-pathogenic bacterial diets on life-history traits in C. elegans models of ND (vs standard OP50). In a first approach, we found 2 bacteria, Escherichia coli K12 and E. coli HB101, able to improve locomotion in liquid media, in worm’s model of Parkinson disease (PD) at adult day 4, versus E. coli OP50. Moreover, an age-dependent locomotion improvement, between larva-L4 and adult day 4, was observed in solid media after feeding PD model´s worms with 4 different bacteria versus E. coli OP50. We also observed an increase in the developmental timing of wild-type worms grown in 4 bacteria versus E. coli OP50, but more interesting was the accelerated developmental rate selectively found in models of PD and Huntington disease feed with E. coli BL21 (DE3). We are currently evaluating aggregate numbers, lifespan and mitochondrial morphology among others. Our results allowed us to identify bacteria with the ability to drive physiological outcomes and improve health status of C. elegans models of neurodegenerative diseases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Genetics Society of America
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MICROBIOTA
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C ELEGANS
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DIETA
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NEURIDEGENERATIVAS
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Otras Ciencias Naturales y Exactas
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Otras Ciencias Naturales y Exactas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Bacterial diets are able to modulate life-history treats in C. elegans models of neurodegenerative diseases
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-07-10T14:13:06Z
dc.journal.pagination
392-392
dc.journal.pais
Reino Unido
dc.journal.ciudad
Glasgow
dc.description.fil
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Burkovski, Andras. Universitat Erlangen-nurnberg. Faculty Of Sciences.; Alemania
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://genetics-gsa.org/celegans2023/program-and-abstract-books/
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
24th International C. elegans Conference
dc.date.evento
2023-07-24
dc.description.ciudadEvento
Glasgow
dc.description.paisEvento
Reino Unido
dc.type.publicacion
Book
dc.description.institucionOrganizadora
Genetics Society of America
dc.source.libro
Abstract book: 24th International C. elegans Conference
dc.source.revista
24th International C. elegans Conference
dc.date.eventoHasta
2023-07-28
dc.type
Congreso
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