Artículo
Venlafaxine besylate monohydrate
Fecha de publicación:
11/2013
Editorial:
International Union of Crystallography
Revista:
Acta Crystallographica Section E: Crystallographic Communications
ISSN:
2056-9890
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The title compound {systematic name: [2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]dimethylazanium benzenesulfonate monohydrate}, C17H28NO2+·C6H5O3S-·H2O, is a besylate salt hydrate of the antidepressant drug venlafaxine. In the crystal, besylate anions and water molecules self-assemble, forming hydrogen-bonded dimers linked around inversion centers, with graph set R44(6). The crystal packing features a chain of alternate dimers and venlafaxine cations in the b-axis direction with the components linked by O-H...O hydrogen bonds and C-H...O and C-H...[pi] interactions. This is the first example of a venlafaxine cation with a closed conformation, as it features an intramolecular N-H...O interaction involving the protonated N atom.
Palabras clave:
Single-Crystal
,
X-Ray Study
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Corvalán Moya, Carolina del Huerto; Vega, Daniel Roberto; Venlafaxine besylate monohydrate; International Union of Crystallography; Acta Crystallographica Section E: Crystallographic Communications; 69; 11-2013; 1737-1738
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