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dc.contributor.author
Sassone, Adriana Haydée
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dc.contributor.author
Testard, Juliana
dc.contributor.author
Saulo, Andrea Celeste
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dc.contributor.author
Julia, Analia
dc.contributor.author
Schaiquevich, Paula Susana
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dc.date.available
2024-06-03T10:48:16Z
dc.date.issued
2023-10
dc.identifier.citation
Sassone, Adriana Haydée; Testard, Juliana; Saulo, Andrea Celeste; Julia, Analia; Schaiquevich, Paula Susana; Treatment of graft versus host disease with photopheresis interferes in voriconazole therapeutic drug monitoring: A case study; Elsevier; Practical Laboratory Medicine; 37; 10-2023; 1-5
dc.identifier.issn
2352-5517
dc.identifier.uri
http://hdl.handle.net/11336/236770
dc.description.abstract
Extracorporeal photopheresis is an established procedure for refractory graft-versus-host disease, a major complication associated with notable morbidity and mortality in patients with allogeneic hematopoietic stem cell transplant. Despite being implemented over a decade ago, there is scant information about potential interactions or analytical interferences with concomitant drugs in this polymedicated population. Here we report the case of a pediatric patient diagnosed with cutaneous steroid-refractory acute graft-versus-host disease after unrelated allogeneic hematopoietic stem cell transplant that was treated with photopheresis. Analytical quantification of voriconazole by HPLC-PDA the day following photopheresis treatment did not permit therapeutic drug monitoring (TDM) due to the presence of interference at the voriconazole retention time. Following investigations, it was demonstrated that the interference is likely attributable to a psoralen-based compound. The interference was not present when samples were obtained prior to photopheresis, enabling TDM. This case underscores the relevance of communication among the members of the treating team to perform reliable TDM, especially in routine clinical practice of pediatric patients with complex diseases undergoing innovative treatments. This finding is relevant to voriconazole quantification by HPLC-PDA, frequently used in laboratories based in middle-income countries.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
PHOTOPHERESIS
dc.subject
VORICONAZOLE
dc.subject
THERAPEUTIC DRUG MONITORING
dc.subject.classification
Hematología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Treatment of graft versus host disease with photopheresis interferes in voriconazole therapeutic drug monitoring: A case study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-05-22T11:35:25Z
dc.journal.volume
37
dc.journal.pagination
1-5
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Sassone, Adriana Haydée. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Testard, Juliana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Saulo, Andrea Celeste. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Julia, Analia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.description.fil
Fil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Practical Laboratory Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.plabm.2023.e00340
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