Artículo
Treatment of graft versus host disease with photopheresis interferes in voriconazole therapeutic drug monitoring: A case study
Sassone, Adriana Haydée; Testard, Juliana; Saulo, Andrea Celeste
; Julia, Analia; Schaiquevich, Paula Susana
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
10/2023
Editorial:
Elsevier
Revista:
Practical Laboratory Medicine
ISSN:
2352-5517
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Extracorporeal photopheresis is an established procedure for refractory graft-versus-host disease, a major complication associated with notable morbidity and mortality in patients with allogeneic hematopoietic stem cell transplant. Despite being implemented over a decade ago, there is scant information about potential interactions or analytical interferences with concomitant drugs in this polymedicated population. Here we report the case of a pediatric patient diagnosed with cutaneous steroid-refractory acute graft-versus-host disease after unrelated allogeneic hematopoietic stem cell transplant that was treated with photopheresis. Analytical quantification of voriconazole by HPLC-PDA the day following photopheresis treatment did not permit therapeutic drug monitoring (TDM) due to the presence of interference at the voriconazole retention time. Following investigations, it was demonstrated that the interference is likely attributable to a psoralen-based compound. The interference was not present when samples were obtained prior to photopheresis, enabling TDM. This case underscores the relevance of communication among the members of the treating team to perform reliable TDM, especially in routine clinical practice of pediatric patients with complex diseases undergoing innovative treatments. This finding is relevant to voriconazole quantification by HPLC-PDA, frequently used in laboratories based in middle-income countries.
Palabras clave:
PHOTOPHERESIS
,
VORICONAZOLE
,
THERAPEUTIC DRUG MONITORING
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Sassone, Adriana Haydée; Testard, Juliana; Saulo, Andrea Celeste; Julia, Analia; Schaiquevich, Paula Susana; Treatment of graft versus host disease with photopheresis interferes in voriconazole therapeutic drug monitoring: A case study; Elsevier; Practical Laboratory Medicine; 37; 10-2023; 1-5
Compartir
Altmétricas