Artículo
Metabolic and molecular effects of dietary extra virgin olive oil in blood and placenta of women with GDM
Gomez Ribot, Dalmiro Leonardo Antonio
; Díaz, Esteban; Fazio, María Victoria; Gomez, Hebe Lorena; Careaga Quiroga, Valeria Pilar
; Maier, Marta Silvia
; Macchi, Silvia; Gresta, Carlos; Capobianco, Evangelina Lorena
; Jawerbaum, Alicia Sandra
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Fecha de publicación:
08/2023
Editorial:
Frontiers Media
Revista:
Frontiers in Endocrinology
ISSN:
1664-2392
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Gestational diabetes mellitus (GDM) increases the risks of maternal, placental, and neonatal complications. Previously, we found that a diet enriched in extra virgin olive oil (EVOO) prevents increased maternal triglyceridemia and placental proinflammatory markers in a cohort of GDM patients. The aim of this work was to evaluate maternal circulating markers of insulin resistance, placental collagen, glycogen and lipid levels, and placental levels of proteins, mRNAs, and a microRNA involved in the endocytic pathway in the same cohort of control women and women with GDM who received or did not receive a diet enriched in EVOO (36 g/day) from weeks 24 to 28 of pregnancy until term. Results: At term, the TG/HDL cholesterol ratio, fatty acid binding protein 4 circulating levels, and maternal BMI were increased in the GDM patients, alterations prevented by the maternal diet enriched in EVOO. Although there were no changes in placental lipid levels and lipid profile, GDM placentas were thicker than controls and showed increased glycogen and collagen content, alterations prevented by the EVOO enriched diet. GDM placentas showed increases in megalin levels, in the expression of several genes involved in the endocytic pathway, and in miR-199, which targets these genes, alterations prevented by the maternal diet enriched in EVOO. Conclusions: We identified novel beneficial effects of an EVOO-enriched diet in GDM women, a diet capable of regulating maternal insulin resistance, the structure and metabolism of the placenta, and the placental endocytic pathway, suggesting effects that may be beneficial for fetal development.
Palabras clave:
EXTRA VIRGIN OLIVE OIL
,
MATERNAL DIABETES
,
METABOLISM
,
MIR-199
,
PLACENTA
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Gomez Ribot, Dalmiro Leonardo Antonio; Díaz, Esteban; Fazio, María Victoria; Gomez, Hebe Lorena; Careaga Quiroga, Valeria Pilar; et al.; Metabolic and molecular effects of dietary extra virgin olive oil in blood and placenta of women with GDM; Frontiers Media; Frontiers in Endocrinology; 14; 8-2023; 1-14
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