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Artículo

B. abortus Infection Promotes an Imbalance in the Adipocyte–Osteoblast Crosstalk Favoring Bone Resorption

Freiberger, Rosa NicoleIcon ; López, Cinthya Alicia Marcela; Sviercz, Franco AgustinIcon ; Cevallos, Cintia GiselaIcon ; Guano, Alex David; Jarmoluk, Patricio; Quarleri, Jorge FabianIcon ; Delpino, María VictoriaIcon
Fecha de publicación: 03/2023
Editorial: Molecular Diversity Preservation International
Revista: International Journal of Molecular Sciences
ISSN: 1422-0067
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Enfermedades Infecciosas

Resumen

Osteoarticular injury is the most common presentation of active brucellosis in humans. Osteoblasts and adipocytes originate from mesenchymal stem cells (MSC). Since those osteoblasts are bone-forming cells, the predilection of MSC to differentiate into adipocytes or osteoblasts is a potential factor involved in bone loss. In addition, osteoblasts and adipocytes can be converted into each other according to the surrounding microenvironment. Here, we study the incumbency of B. abortus infection in the crosstalk between adipocytes and osteoblasts during differentiation from its precursors. Our results indicate that soluble mediators present in culture supernatants from B. abotus-infected adipocytes inhibit osteoblast mineral matrix deposition in a mechanism dependent on the presence of IL-6 with the concomitant reduction of Runt-related transcription factor 2 (RUNX-2) transcription, but without altering organic matrix deposition and inducing nuclear receptor activator ligand kβ (RANKL) expression. Secondly, B. abortus-infected osteoblasts stimulate adipocyte differentiation with the induction of peroxisome proliferator-activated receptor γ (PPAR-γ) and CCAAT enhancer binding protein β (C/EBP-β). We conclude that adipocyte–osteoblast crosstalk during B. abortus infection could modulate mutual differentiation from its precursor cells, contributing to bone resorption.
Palabras clave: ADIPOCYTE , BRUCELLA , IL-6 , OSTEOBLAST , PPAR-Γ , RUNX-2
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/227808
URL: https://www.mdpi.com/1422-0067/24/6/5617
DOI: http://dx.doi.org/10.3390/ijms24065617
Colecciones
Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Citación
Freiberger, Rosa Nicole; López, Cinthya Alicia Marcela; Sviercz, Franco Agustin; Cevallos, Cintia Gisela; Guano, Alex David; et al.; B. abortus Infection Promotes an Imbalance in the Adipocyte–Osteoblast Crosstalk Favoring Bone Resorption; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 24; 6; 3-2023; 1-16
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