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dc.contributor.author
Naipauer, Julian
dc.contributor.author
Mesri, Enrique Alfredo
dc.date.available
2024-02-02T14:22:41Z
dc.date.issued
2023-01
dc.identifier.citation
Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-200
dc.identifier.issn
1471-4914
dc.identifier.uri
http://hdl.handle.net/11336/225598
dc.description.abstract
Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ANGIOGENESIS
dc.subject
ENDOTHELIAL-TO-MESENCHYMAL DIFFERENTIATION AXIS
dc.subject
KAPOSI´S SARCOMA HERPESVIRUS
dc.subject
SARCOMAGENESIS
dc.subject
VIRUS ONCOGENESIS
dc.subject.classification
Virología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-01T15:44:57Z
dc.journal.volume
29
dc.journal.number
3
dc.journal.pagination
188-200
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Naipauer, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Mesri, Enrique Alfredo. University of Miami; Estados Unidos
dc.journal.title
Trends In Molecular Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molmed.2022.12.003
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