Artículo
The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis
Fecha de publicación:
01/2023
Editorial:
Elsevier
Revista:
Trends In Molecular Medicine
ISSN:
1471-4914
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Endothelial-to-mesenchymal transition has been described in tumors as a source of mesenchymal stroma, while the reverse process has been proposed in tumor vasculogenesis and angiogenesis. A human oncogenic virus, Kaposi's sarcoma herpes virus (KSHV), can regulate both processes in order to transit through this transition ‘boulevard’ when infecting KS oncogenic progenitor cells. Endothelial or mesenchymal circulating progenitor cells can serve as KS oncogenic progenitors recruited by inflammatory cytokines because KSHV can reprogram one into the other through endothelial-to-mesenchymal and mesenchymal-to-endothelial transitions. Through these novel insights, the identity of the potential oncogenic progenitor of KS is revealed while gaining knowledge of the biology of the mesenchymal-endothelial differentiation axis and pointing to this axis as a therapeutic target in KS.
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Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Naipauer, Julian; Mesri, Enrique Alfredo; The Kaposi's sarcoma progenitor enigma: KSHV-induced MEndT–EndMT axis; Elsevier; Trends In Molecular Medicine; 29; 3; 1-2023; 188-200
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