Artículo
Impaired Reverse Cholesterol Transport is Associated with Changes in Fatty Acid Profile in Children and Adolescents with Abdominal Obesity
Martin, Maximiliano; Impa Condori, Anabel Rocío; Davico, Belen
; Gomez Rosso, Leonardo Adrián
; Gaete, Laura; Tetzlaff, Walter Francisco
; Lozano Chiappe, Ezequiel Silvano
; Saez, Maria Soledad; Lorenzon González, María Victoria; Godoy, Maria Fernanda; Osta, Viviana; Trifone, Liliana; Ballerini, Maria Gabriela; Cherñavsky, Alejandra Claudia
; Boero, Laura; Tonietti, Miriam; Feliu, María Susana; Brites, Fernando Daniel
Fecha de publicación:
09/2023
Editorial:
Amer Soc Nutritional Science
Revista:
Journal Of Nutrition
ISSN:
0022-3166
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: Abdominal obesity is an important cardiovascular disease risk factor. Plasma fatty acids display a complex network of both pro and antiatherogenic effects. High density lipoproteins (HDL) carry out the antiatherogenic pathway called reverse cholesterol transport (RCT), which involves cellular cholesterol efflux (CCE), and lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) activities. Objectives: Our aim was to characterize RCT and its relation to fatty acids present in plasma in pediatric abdominal obesity. Methods: Seventeen children and adolescents with abdominal obesity and 17 healthy controls were studied. Anthropometric parameters were registered. Glucose, insulin, lipid levels, CCE employing THP-1 cells, LCAT and CETP activities, plus fatty acids in apo B-depleted plasma were measured. Results: The obese group showed a more atherogenic lipid profile, plus lower CCE (Mean±Standard Deviation) (6 ± 2 vs. 7 ± 2%; P < 0.05) and LCAT activity (11 ± 3 vs. 15 ±5 umol/dL.h; P < 0.05). With respect to fatty acids, the obese group showed higher myristic (1.1 ± 0.3 vs. 0.7 ± 0.3; P < 0.01) and palmitic acids (21.5 ± 2.8 vs. 19.6 ± 1.9; P < 0.05) in addition to lower linoleic acid (26.4 ± 3.3 vs. 29.9 ± 2.6; P < 0.01). Arachidonic acid correlated with CCE (r = 0.37; P < 0.05), myristic acid with LCAT (r = -0.37; P < 0.05), palmitioleic acid with CCE (r = -0.35; P < 0.05), linoleic acid with CCE (r = 0.37; P < 0.05), lauric acid with LCAT (r = 0.49; P < 0.05), myristic acid with LCAT (r = -0.37; P < 0.05) ecoisatrienoic acid with CCE (r = 0.40; P < 0.05) and lignoseric acid with LCAT (r = -0.5; P < 0.01). Conclusions: Children and adolescents with abdominal obesity presented impaired RCT, which was associated with modifications in proinflammatory fatty acids, such as palmitoleic and myristic, thus contributing to increased cardiovascular disease risk.
Palabras clave:
ABDOMINAL OBESITY
,
CETP
,
CHOLESTEROL EFFLUX
,
FATTY ACID PROFILE
,
HDL
,
LCAT
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Martin, Maximiliano; Impa Condori, Anabel Rocío; Davico, Belen; Gomez Rosso, Leonardo Adrián; Gaete, Laura; et al.; Impaired Reverse Cholesterol Transport is Associated with Changes in Fatty Acid Profile in Children and Adolescents with Abdominal Obesity; Amer Soc Nutritional Science; Journal Of Nutrition; 154; 1; 9-2023; 12-25
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