Artículo
Triclabendazole and clofazimine reduce replication and spermine uptake in vitro in Toxoplasma gondii
Corvi, Maria Martha
; Rossi, Franco Rubén
; Ganuza, Agustina; Alonso, Andrés Mariano
; Alberca, Lucas Nicolás
; Dietrich, Roque Carlos
; Gavernet, Luciana
; Talevi, Alan
Fecha de publicación:
12/2023
Editorial:
Springer
Revista:
Parasitology Research
ISSN:
0932-0113
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Toxoplasmosis is a worldwide zoonosis caused by the protozoan parasite Toxoplasma gondii. Although this infection is generally asymptomatic in immunocompetent individuals, it can cause serious clinical manifestations in newborns with congenital infection or in immunocompromised patients. As current treatments are not always well tolerated, there is an urgent need to find new drugs against human toxoplasmosis. Drug repurposing has gained considerable momentum in the last decade and is a particularly attractive approach for the search of therapeutic alternatives to treat rare and neglected diseases. Thus, in this study, we investigated the antiproliferative effect of several repurposed drugs. Of these, clofazimine and triclabendazole displayed a higher selectivity against T. gondii, affecting its replication. Furthermore, both compounds inhibited spermine incorporation into the parasite, which is necessary for the formation of other polyamines. The data reported here indicate that clofazimine and triclabendazole could be used for the treatment of human toxoplasmosis and confirms that drug repurposing is an excellent strategy to find new therapeutic targets of intervention.
Palabras clave:
DRUG REPURPOSING
,
POLYAMINE TRANSPORT
,
TOXOPLASMA GONDII
,
TOXOPLASMOSIS
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Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Corvi, Maria Martha; Rossi, Franco Rubén; Ganuza, Agustina; Alonso, Andrés Mariano; Alberca, Lucas Nicolás; et al.; Triclabendazole and clofazimine reduce replication and spermine uptake in vitro in Toxoplasma gondii; Springer; Parasitology Research; 123; 1; 12-2023; 1-7
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