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dc.contributor.author
Degiuseppe, Juan Ignacio
dc.contributor.author
Torres, Carolina
dc.contributor.author
Mbayed, Viviana Andrea
dc.contributor.author
Stupka, Juan Andrés
dc.date.available
2024-01-17T14:03:11Z
dc.date.issued
2022-10
dc.identifier.citation
Degiuseppe, Juan Ignacio; Torres, Carolina; Mbayed, Viviana Andrea; Stupka, Juan Andrés; Phylogeography of Rotavirus G8P[8] Detected in Argentina: Evidence of Transpacific Dissemination; MDPI; Viruses; 14; 10; 10-2022; 1-6
dc.identifier.issn
1999-4915
dc.identifier.uri
http://hdl.handle.net/11336/223957
dc.description.abstract
Rotavirus is one of the leading causes of diarrhea in children. In 2018, G8P[8], an unusual association of genotypes, was detected with moderate frequency in symptomatic children in Argen-tina, unlike a previous sporadic identification in 2016. The aim of this study was to analyze the dissemination pattern of the G8P[8]-lineage IV strains detected in Argentina. Nucleotide sequences of the VP7 gene of Argentine G8P[8] strains (2016, 2018 and 2019) were studied by discrete phylodynamic analyses, together with other worldwide relevant G8-lineage IV strains. Bayes Factor (BF) was used to assess the strength of the epidemiological association between countries. Phylodynamic analyses determined an evolutionary rate of 3.7 × 10−3 (HDP95%: 1.4 × 10−3–8.2 × 10−3) substitutions/site/year. Likewise, the most recent common ancestor was 32.2 years old, dating back to 1986 (HDP95% = 1984–1988). The spatiotemporal dynamics analysis revealed South Korea as being the country of origin of the Argentine strains (posterior probability of the ancestral state: 0.8471), which was also evidenced by a significant rate of diffusion from South Korea to Argentina (BF: 55.1). The detection of G8 in South America in 2016–2017 was not related to the cases detected in 2018–2019, revealing a new G8 introduction to the region and supporting a transpacific dissemination.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ARGENTINA
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BAYESIAN ANALYSIS
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G8P[8]
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PHYLODYNAMICS
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ROTAVIRUS
dc.subject.classification
Enfermedades Infecciosas
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Phylogeography of Rotavirus G8P[8] Detected in Argentina: Evidence of Transpacific Dissemination
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-17T11:28:54Z
dc.journal.volume
14
dc.journal.number
10
dc.journal.pagination
1-6
dc.journal.pais
Suiza
dc.description.fil
Fil: Degiuseppe, Juan Ignacio. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina
dc.description.fil
Fil: Torres, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y BioquÍmica. Instituto de Investigaciones En Bacteriología y Virología Molecular (IBaViM); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Mbayed, Viviana Andrea. Universidad de Buenos Aires. Facultad de Farmacia y BioquÍmica. Instituto de Investigaciones En Bacteriología y Virología Molecular (IBaViM); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Stupka, Juan Andrés. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina
dc.journal.title
Viruses
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/v14102223
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