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Artículo

Phylogeography of Rotavirus G8P[8] Detected in Argentina: Evidence of Transpacific Dissemination

Degiuseppe, Juan Ignacio; Torres, CarolinaIcon ; Mbayed, Viviana AndreaIcon ; Stupka, Juan Andrés
Fecha de publicación: 10/2022
Editorial: MDPI
Revista: Viruses
ISSN: 1999-4915
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Enfermedades Infecciosas

Resumen

Rotavirus is one of the leading causes of diarrhea in children. In 2018, G8P[8], an unusual association of genotypes, was detected with moderate frequency in symptomatic children in Argen-tina, unlike a previous sporadic identification in 2016. The aim of this study was to analyze the dissemination pattern of the G8P[8]-lineage IV strains detected in Argentina. Nucleotide sequences of the VP7 gene of Argentine G8P[8] strains (2016, 2018 and 2019) were studied by discrete phylodynamic analyses, together with other worldwide relevant G8-lineage IV strains. Bayes Factor (BF) was used to assess the strength of the epidemiological association between countries. Phylodynamic analyses determined an evolutionary rate of 3.7 × 10−3 (HDP95%: 1.4 × 10−3–8.2 × 10−3) substitutions/site/year. Likewise, the most recent common ancestor was 32.2 years old, dating back to 1986 (HDP95% = 1984–1988). The spatiotemporal dynamics analysis revealed South Korea as being the country of origin of the Argentine strains (posterior probability of the ancestral state: 0.8471), which was also evidenced by a significant rate of diffusion from South Korea to Argentina (BF: 55.1). The detection of G8 in South America in 2016–2017 was not related to the cases detected in 2018–2019, revealing a new G8 introduction to the region and supporting a transpacific dissemination.
Palabras clave: ARGENTINA , BAYESIAN ANALYSIS , G8P[8] , PHYLODYNAMICS , ROTAVIRUS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/223957
DOI: http://dx.doi.org/10.3390/v14102223
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Degiuseppe, Juan Ignacio; Torres, Carolina; Mbayed, Viviana Andrea; Stupka, Juan Andrés; Phylogeography of Rotavirus G8P[8] Detected in Argentina: Evidence of Transpacific Dissemination; MDPI; Viruses; 14; 10; 10-2022; 1-6
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