Artículo
Naringin: nanotechnological strategies for potential pharmaceutical applications
Ravetti, Soledad
; Garro, Ariel Gustavo; Gaitán, Agustina
; Murature, Mariano; Galiano, Mariela; Brignone, Sofía Gisella
; Palma, Santiago Daniel
Fecha de publicación:
03/2023
Editorial:
MDPI
Revista:
Pharmaceutics
ISSN:
1999-4923
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Polyphenols comprise a number of natural substances, such as flavonoids, that show interesting biological effects. Among these substances is naringin, a naturally occurring flavanone glycoside found in citrus fruits and Chinese medicinal herbs. Several studies have shown that naringin has numerous biological properties, including cardioprotective, cholesterol-lowering, anti-Alzheimer’s, nephroprotective, antiageing, antihyperglycemic, antiosteoporotic and gastroprotective, anti-inflammatory, antioxidant, antiapoptotic, anticancer and antiulcer effects. Despite its multiple benefits, the clinical application of naringin is severely restricted due to its susceptibility to oxidation, poor water solubility, and dissolution rate. In addition, naringin shows instability at acidic pH, is enzymatically metabolized by β-glycosidase in the stomach and is degraded in the bloodstream when administered intravenously. These limitations, however, have been overcome thanks to the development of naringin nanoformulations. This review summarizes recent research carried out on strategies designed to improve naringin’s bioactivity for potential therapeutic applications.
Palabras clave:
BIOAVAILABILITY
,
DRUG DELIVERY
,
NANOFORMULATION
,
NARINGIN
,
NATURAL PRODUCTS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Ravetti, Soledad; Garro, Ariel Gustavo; Gaitán, Agustina; Murature, Mariano; Galiano, Mariela; et al.; Naringin: nanotechnological strategies for potential pharmaceutical applications; MDPI; Pharmaceutics; 15; 3; 3-2023; 863-870
Compartir
Altmétricas