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dc.contributor.author
Barrutieta Arberas, I.
dc.contributor.author
Ortuzar, N.
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Vaquero Rodríguez, A.
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Picó-Gallardo, M.
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Bengoetxea, H.
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Guevara, M. A.
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Gargiulo, Pascual Angel
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dc.contributor.author
Lafuente, J. V.
dc.date.available
2024-01-03T15:52:21Z
dc.date.issued
2023-05
dc.identifier.citation
Barrutieta Arberas, I.; Ortuzar, N.; Vaquero Rodríguez, A.; Picó-Gallardo, M.; Bengoetxea, H.; et al.; The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus; Soc Experimental Biology Medicine; Experimental Biology And Medicine; 248; 7; 5-2023; 588-595
dc.identifier.issn
1535-3702
dc.identifier.uri
http://hdl.handle.net/11336/222316
dc.description.abstract
Major depressive disorder (MDD) is a complex illness that is arising as a growing public health concern. Although several brain areas are related to this type of disorders, at the cellular level, the parvalbumin-positive cells of the hippocampus interplay a very relevant role. They control pyramidal cell bursts, neuronal networks, basic microcircuit functions, and other complex neuronal tasks involved in mood disorders. In resistant depressions, the efficacy of current antidepressant treatments drops dramatically, so the new rapid-acting antidepressants (RAADs) are being postulated as novel treatments. Ketamine at subanesthetic doses and its derivative metabolites have been proposed as RAADs due to their rapid and sustained action by blocking N-methyl-d-aspartate (NMDA) receptors, which in turn lead to the release of brain-derived neurotrophic factor (BDNF). This mechanism produces a rapid plasticity activation mediated by neurotransmitter homeostasis, synapse recovery, and increased dendritic spines and therefore, it is a promising therapeutic approach to improve cognitive symptoms in MDD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Soc Experimental Biology Medicine
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)
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HIPPOCAMPUS (HC)
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INTERNEURONS (INS)
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KETAMINE
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MAJOR DEPRESSIVE DISORDER (MDD)
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N-METHYL-D-ASPARTATE RECEPTORS (NMDARS)
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Psiquiatría
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-03T12:43:24Z
dc.journal.volume
248
dc.journal.number
7
dc.journal.pagination
588-595
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Barrutieta Arberas, I.. Universidad del País Vasco; España
dc.description.fil
Fil: Ortuzar, N.. Universidad del País Vasco; España
dc.description.fil
Fil: Vaquero Rodríguez, A.. Universidad del País Vasco; España
dc.description.fil
Fil: Picó-Gallardo, M.. Universidad del País Vasco; España
dc.description.fil
Fil: Bengoetxea, H.. Universidad del País Vasco; España
dc.description.fil
Fil: Guevara, M. A.. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
dc.description.fil
Fil: Lafuente, J. V.. Universidad del País Vasco; España
dc.journal.title
Experimental Biology And Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/15353702231170007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/15353702231170007
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