Artículo
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus
Barrutieta Arberas, I.; Ortuzar, N.; Vaquero Rodríguez, A.; Picó-Gallardo, M.; Bengoetxea, H.; Guevara, M. A.; Gargiulo, Pascual Angel
; Lafuente, J. V.
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
05/2023
Editorial:
Soc Experimental Biology Medicine
Revista:
Experimental Biology And Medicine
ISSN:
1535-3702
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Major depressive disorder (MDD) is a complex illness that is arising as a growing public health concern. Although several brain areas are related to this type of disorders, at the cellular level, the parvalbumin-positive cells of the hippocampus interplay a very relevant role. They control pyramidal cell bursts, neuronal networks, basic microcircuit functions, and other complex neuronal tasks involved in mood disorders. In resistant depressions, the efficacy of current antidepressant treatments drops dramatically, so the new rapid-acting antidepressants (RAADs) are being postulated as novel treatments. Ketamine at subanesthetic doses and its derivative metabolites have been proposed as RAADs due to their rapid and sustained action by blocking N-methyl-d-aspartate (NMDA) receptors, which in turn lead to the release of brain-derived neurotrophic factor (BDNF). This mechanism produces a rapid plasticity activation mediated by neurotransmitter homeostasis, synapse recovery, and increased dendritic spines and therefore, it is a promising therapeutic approach to improve cognitive symptoms in MDD.
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Articulos(CCT - MENDOZA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MENDOZA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MENDOZA
Citación
Barrutieta Arberas, I.; Ortuzar, N.; Vaquero Rodríguez, A.; Picó-Gallardo, M.; Bengoetxea, H.; et al.; The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus; Soc Experimental Biology Medicine; Experimental Biology And Medicine; 248; 7; 5-2023; 588-595
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