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dc.contributor.author
Rosso, Silvana Beatriz
dc.contributor.author
Inestrosa, Nibaldo C.
dc.date.available
2017-08-04T20:17:34Z
dc.date.issued
2013-07
dc.identifier.citation
Rosso, Silvana Beatriz; Inestrosa, Nibaldo C.; WNT signaling in neuronal maturation and synaptogenesis; Frontiers; Frontiers in Cellular Neuroscience; 7; 103; 7-2013; 194-205
dc.identifier.issn
1662-5102
dc.identifier.uri
http://hdl.handle.net/11336/21909
dc.description.abstract
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key regulators of a variety of developmental processes, including embryonic patterning, cell specification, and cell polarity. In the nervous system, Wnt signaling also regulates the formation and function of neuronal circuits by controlling neuronal differentiation, axon outgrowth and guidance, dendrite development, synaptic function, and neuronal plasticity. Wnt factors can signal through three very well characterized cascades: canonical or β-catenin pathway, planar cell polarity pathway and calcium pathway that control different processes. However, divergent downstream cascades have been identified to control neuronal morphogenesis. In the nervous system, the expression of Wnt proteins is a highly controlled process. In addition, deregulation of Wnt signaling has been associated with neurodegenerative diseases. Here, we will review different aspects of neuronal and dendrite maturation, including spinogenesis and synaptogenesis. Finally, the role of Wnt pathway components on Alzheimer’s disease will be revised.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Wnt Proteins
dc.subject
Dendritogenesis
dc.subject
Synases
dc.subject
Neuronal Development
dc.subject.classification
Ética Médica
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
WNT signaling in neuronal maturation and synaptogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-04T13:48:40Z
dc.journal.volume
7
dc.journal.number
103
dc.journal.pagination
194-205
dc.journal.pais
Suiza
dc.description.fil
Fil: Rosso, Silvana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Inestrosa, Nibaldo C.. Pontificia Universidad Católica de Chile; Chile
dc.journal.title
Frontiers in Cellular Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fncel.2013.00103
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncel.2013.00103/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829478/
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