Mostrar el registro sencillo del ítem

dc.contributor.author
Rosso, Silvana Beatriz  
dc.contributor.author
Inestrosa, Nibaldo C.  
dc.date.available
2017-08-04T20:17:34Z  
dc.date.issued
2013-07  
dc.identifier.citation
Rosso, Silvana Beatriz; Inestrosa, Nibaldo C.; WNT signaling in neuronal maturation and synaptogenesis; Frontiers; Frontiers in Cellular Neuroscience; 7; 103; 7-2013; 194-205  
dc.identifier.issn
1662-5102  
dc.identifier.uri
http://hdl.handle.net/11336/21909  
dc.description.abstract
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key regulators of a variety of developmental processes, including embryonic patterning, cell specification, and cell polarity. In the nervous system, Wnt signaling also regulates the formation and function of neuronal circuits by controlling neuronal differentiation, axon outgrowth and guidance, dendrite development, synaptic function, and neuronal plasticity. Wnt factors can signal through three very well characterized cascades: canonical or β-catenin pathway, planar cell polarity pathway and calcium pathway that control different processes. However, divergent downstream cascades have been identified to control neuronal morphogenesis. In the nervous system, the expression of Wnt proteins is a highly controlled process. In addition, deregulation of Wnt signaling has been associated with neurodegenerative diseases. Here, we will review different aspects of neuronal and dendrite maturation, including spinogenesis and synaptogenesis. Finally, the role of Wnt pathway components on Alzheimer’s disease will be revised.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Wnt Proteins  
dc.subject
Dendritogenesis  
dc.subject
Synases  
dc.subject
Neuronal Development  
dc.subject.classification
Ética Médica  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
WNT signaling in neuronal maturation and synaptogenesis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-08-04T13:48:40Z  
dc.journal.volume
7  
dc.journal.number
103  
dc.journal.pagination
194-205  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Rosso, Silvana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Inestrosa, Nibaldo C.. Pontificia Universidad Católica de Chile; Chile  
dc.journal.title
Frontiers in Cellular Neuroscience  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fncel.2013.00103  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncel.2013.00103/full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829478/