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Artículo

WNT signaling in neuronal maturation and synaptogenesis

Rosso, Silvana BeatrizIcon ; Inestrosa, Nibaldo C.
Fecha de publicación: 07/2013
Editorial: Frontiers
Revista: Frontiers in Cellular Neuroscience
ISSN: 1662-5102
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Ética Médica

Resumen

The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system. Wnt components are key regulators of a variety of developmental processes, including embryonic patterning, cell specification, and cell polarity. In the nervous system, Wnt signaling also regulates the formation and function of neuronal circuits by controlling neuronal differentiation, axon outgrowth and guidance, dendrite development, synaptic function, and neuronal plasticity. Wnt factors can signal through three very well characterized cascades: canonical or β-catenin pathway, planar cell polarity pathway and calcium pathway that control different processes. However, divergent downstream cascades have been identified to control neuronal morphogenesis. In the nervous system, the expression of Wnt proteins is a highly controlled process. In addition, deregulation of Wnt signaling has been associated with neurodegenerative diseases. Here, we will review different aspects of neuronal and dendrite maturation, including spinogenesis and synaptogenesis. Finally, the role of Wnt pathway components on Alzheimer’s disease will be revised.
Palabras clave: Wnt Proteins , Dendritogenesis , Synases , Neuronal Development
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/21909
DOI: http://dx.doi.org/10.3389/fncel.2013.00103
URL: http://journal.frontiersin.org/article/10.3389/fncel.2013.00103/full
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829478/
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Rosso, Silvana Beatriz; Inestrosa, Nibaldo C.; WNT signaling in neuronal maturation and synaptogenesis; Frontiers; Frontiers in Cellular Neuroscience; 7; 103; 7-2013; 194-205
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