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dc.contributor.author
Tamayo Castillo, Giselle  
dc.contributor.author
Vásquez, Victor  
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Ríos, Maria Isabel  
dc.contributor.author
Rodriguez, María Victoria  
dc.contributor.author
Solano, Godofredo  
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Zacchino, Susana Alicia Stella  
dc.contributor.author
Gupta, Mahabir P.  
dc.date.available
2017-08-03T18:00:52Z  
dc.date.issued
2013-02  
dc.identifier.citation
Tamayo Castillo, Giselle; Vásquez, Victor; Ríos, Maria Isabel; Rodriguez, María Victoria; Solano, Godofredo; et al.; Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities; Georg Thieme Verlag Kg; Planta Medica; 79; 18; 2-2013; 1749-1755  
dc.identifier.issn
0032-0943  
dc.identifier.uri
http://hdl.handle.net/11336/21815  
dc.description.abstract
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Georg Thieme Verlag Kg  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Godmania Aesculifolia  
dc.subject
Lapachol  
dc.subject
Chavicol Diglycoside  
dc.subject
Bignoniaceae  
dc.subject.classification
Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-21T19:05:30Z  
dc.journal.volume
79  
dc.journal.number
18  
dc.journal.pagination
1749-1755  
dc.journal.pais
Alemania  
dc.description.fil
Fil: Tamayo Castillo, Giselle. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa Rica  
dc.description.fil
Fil: Vásquez, Victor. Instituto Nacional de Biodiversidad; Costa Rica  
dc.description.fil
Fil: Ríos, Maria Isabel. Instituto Nacional de Biodiversidad; Costa Rica  
dc.description.fil
Fil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Solano, Godofredo. Universidad de Costa Rica; Costa Rica. Instituto Nacional de Biodiversidad; Costa Rica  
dc.description.fil
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Gupta, Mahabir P.. Universidad de Panama; Panamá  
dc.journal.title
Planta Medica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0033-1351025  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1351025  

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