Artículo
Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
Tamayo Castillo, Giselle; Vásquez, Victor; Ríos, Maria Isabel; Rodriguez, María Victoria
; Solano, Godofredo; Zacchino, Susana Alicia Stella; Gupta, Mahabir P.
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Fecha de publicación:
02/2013
Editorial:
Georg Thieme Verlag Kg
Revista:
Planta Medica
ISSN:
0032-0943
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
Palabras clave:
Godmania Aesculifolia
,
Lapachol
,
Chavicol Diglycoside
,
Bignoniaceae
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Citación
Tamayo Castillo, Giselle; Vásquez, Victor; Ríos, Maria Isabel; Rodriguez, María Victoria; Solano, Godofredo; et al.; Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities; Georg Thieme Verlag Kg; Planta Medica; 79; 18; 2-2013; 1749-1755
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