Artículo

N-ethyltetramethylguanidinium ionic liquid [ETMG][EtSO3] as organocatalyst and solvent for facile amide synthesis by formyl-transfer with N-formyl-saccharin

Malunavar, Shruti S.; Anchi, Athmanand; Prabhala, Pavankumar; Kalkhambkar, Rajesh G.; Borosky, Gabriela LeonorIcon ; Laali, Kenneth K.
Fecha de publicación: 17/08/2022
Editorial: Pergamon-Elsevier Science Ltd
Revista: Tetrahedron Letters
ISSN: 0040-4039
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

We report a simple and highly efficient, acid and metal free, method for the synthesis of libraries of primary and secondary formamides employing N-ethyltetramethylguanidinium IL, [ETMG][EtOSO3] as dual organocatalyst and solvent, and N-formyl-saccharin (N-formyl-SAC) as formyl-transfer agent. Good to excellent isolated yields are achieved at r.t. within minutes under sonication. A rational for the efficacy of this organocatalyst is provided by DFT computations.
Palabras clave: AMIDE SYNTHESIS , DFT COMPUTATIONS , N-ETHYLTETRAMETHYLGUANIDINIUM SALT AS ORGANOCATALYST , N-FORMYL-SAC , RECYCLING/REUSE
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/218083
DOI: http://dx.doi.org/10.1016/j.tetlet.2022.153990
Colecciones
Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Malunavar, Shruti S.; Anchi, Athmanand; Prabhala, Pavankumar; Kalkhambkar, Rajesh G.; Borosky, Gabriela Leonor; et al.; N-ethyltetramethylguanidinium ionic liquid [ETMG][EtSO3] as organocatalyst and solvent for facile amide synthesis by formyl-transfer with N-formyl-saccharin; Pergamon-Elsevier Science Ltd; Tetrahedron Letters; 104; 17-8-2022; 1-6
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