Artículo
Crystal structure of Staphylococcal Enterotoxin G (SEG) in complex with a mouse T-cell receptor β chain
Fernández, Marisa Mariel
; Cho, Sangwoo; de Marzi, Mauricio Cesar
; Kerzic, Melissa C.; Robinson, Howard; Mariuzza, Roy A.; Malchiodi, Emilio Luis
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
01/2011
Editorial:
Elsevier
Revista:
Journal of Biological Chemistry (online)
ISSN:
0021-9258
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Superantigens (SAgs) are bacterial or viral toxins that bind MHC class II (MHC-II) molecules and T-cell receptor (TCR) in a nonconventional manner, inducing T-cell activation that leads to inflammatory cytokine production, which may result in acute toxic shock. In addition, the emerging threat of purpura fulminans and community-associated meticillin-resistant Staphylococcus aureus emphasizes the importance of a better characterization of SAg binding to their natural ligands that may allow the development of reagents to neutralize their action. The three-dimensional structure of the complex between a mouse TCR β chain (mVβ8.2) and staphylococcal enterotoxin G (SEG) at 2.0 Å resolution revealed a binding site that does not conserve the "hot spots" present in mVβ8.2-SEC2, mVβ8.2-SEC3, mVβ8.2-SEB, and mVβ8.2-SPEA complexes. Analysis of the mVβ8.2-SEG interface allowed us to explain the higher affinity of this complex compared with the others, which may account for the early activation of T-cells bearing mVβ8.2 by SEG. This mode of interaction between SEG and mVβ8.2 could be an adaptive advantage to bestow on the pathogen a faster rate of colonization of the host.
Palabras clave:
SUPERANTIGENS
,
T CELL RECEPTOR
,
CRYSTAL STRUCTURE
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Colecciones
Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Citación
Fernández, Marisa Mariel; Cho, Sangwoo; de Marzi, Mauricio Cesar; Kerzic, Melissa C.; Robinson, Howard; et al.; Crystal structure of Staphylococcal Enterotoxin G (SEG) in complex with a mouse T-cell receptor β chain; Elsevier; Journal of Biological Chemistry (online); 286; 2; 1-2011; 1189-1195
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