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dc.contributor.author
Song, Chen
dc.contributor.author
Boly, Melanie
dc.contributor.author
Tagliazucchi, Enzo Rodolfo
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dc.contributor.author
Laufs, Helmut
dc.contributor.author
Tononi, Giulio
dc.date.available
2023-11-03T17:59:25Z
dc.date.issued
2022-07
dc.identifier.citation
Song, Chen; Boly, Melanie; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Tononi, Giulio; fMRI spectral signatures of sleep; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 119; 30; 7-2022; 1-12
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/216997
dc.description.abstract
Sleep can be distinguished from wake by changes in brain electrical activity, typically assessed using electroencephalography (EEG). The hallmark of nonrapid-eye-movement (NREM) sleep is the shift from high-frequency, low-amplitude wake EEG to low-frequency, high-amplitude sleep EEG dominated by spindles and slow waves. Here we identified signatures of sleep in brain hemodynamic activity, using simultaneous functional MRI (fMRI) and EEG. We found that, at the transition from wake to sleep, fMRI blood oxygen level–dependent (BOLD) activity evolved from a mixed-frequency pattern to one dominated by two distinct oscillations: a low-frequency (<0.1 Hz) oscillation prominent in light sleep and correlated with the occurrence of spindles, and a high-frequency oscillation (>0.1 Hz) prominent in deep sleep and correlated with the occurrence of slow waves. The two oscillations were both detectable across the brain but exhibited distinct spatiotemporal patterns. During the falling-asleep process, the low-frequency oscillation first appeared in the thalamus, then the posterior cortex, and lastly the frontal cortex, while the high-frequency oscillation first appeared in the midbrain, then the frontal cortex, and lastly the posterior cortex. During the waking-up process, both oscillations disappeared first from the thalamus, then the frontal cortex, and lastly the posterior cortex. The BOLD oscillations provide local signatures of spindle and slow wave activity. They may be employed to monitor the regional occurrence of sleep or wakefulness, track which regions are the first to fall asleep or wake up at the wake–sleep transitions, and investigate local homeostatic sleep processes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy of Sciences
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BOLD OSCILLATIONS
dc.subject
FMRI-EEG
dc.subject
SLEEP
dc.subject
WAKE–SLEEP TRANSITIONS
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
fMRI spectral signatures of sleep
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-30T16:13:56Z
dc.journal.volume
119
dc.journal.number
30
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington D.C
dc.description.fil
Fil: Song, Chen. University of Wisconsin; Estados Unidos. Cardiff University; Reino Unido
dc.description.fil
Fil: Boly, Melanie. University of Wisconsin; Estados Unidos
dc.description.fil
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Adolfo Ibañez; Chile
dc.description.fil
Fil: Laufs, Helmut. University Hospital Schleswig Holstein; Alemania. Goethe Universitat Frankfurt; Alemania
dc.description.fil
Fil: Tononi, Giulio. University of Wisconsin; Estados Unidos
dc.journal.title
Proceedings of the National Academy of Sciences of The United States of America
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/doi/full/10.1073/pnas.2016732119
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.2016732119
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