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Artículo

fMRI spectral signatures of sleep

Song, Chen; Boly, Melanie; Tagliazucchi, Enzo RodolfoIcon ; Laufs, Helmut; Tononi, Giulio
Fecha de publicación: 07/2022
Editorial: National Academy of Sciences
Revista: Proceedings of the National Academy of Sciences of The United States of America
ISSN: 0027-8424
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Físicas

Resumen

Sleep can be distinguished from wake by changes in brain electrical activity, typically assessed using electroencephalography (EEG). The hallmark of nonrapid-eye-movement (NREM) sleep is the shift from high-frequency, low-amplitude wake EEG to low-frequency, high-amplitude sleep EEG dominated by spindles and slow waves. Here we identified signatures of sleep in brain hemodynamic activity, using simultaneous functional MRI (fMRI) and EEG. We found that, at the transition from wake to sleep, fMRI blood oxygen level–dependent (BOLD) activity evolved from a mixed-frequency pattern to one dominated by two distinct oscillations: a low-frequency (<0.1 Hz) oscillation prominent in light sleep and correlated with the occurrence of spindles, and a high-frequency oscillation (>0.1 Hz) prominent in deep sleep and correlated with the occurrence of slow waves. The two oscillations were both detectable across the brain but exhibited distinct spatiotemporal patterns. During the falling-asleep process, the low-frequency oscillation first appeared in the thalamus, then the posterior cortex, and lastly the frontal cortex, while the high-frequency oscillation first appeared in the midbrain, then the frontal cortex, and lastly the posterior cortex. During the waking-up process, both oscillations disappeared first from the thalamus, then the frontal cortex, and lastly the posterior cortex. The BOLD oscillations provide local signatures of spindle and slow wave activity. They may be employed to monitor the regional occurrence of sleep or wakefulness, track which regions are the first to fall asleep or wake up at the wake–sleep transitions, and investigate local homeostatic sleep processes.
Palabras clave: BOLD OSCILLATIONS , FMRI-EEG , SLEEP , WAKE–SLEEP TRANSITIONS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/216997
URL: https://www.pnas.org/doi/full/10.1073/pnas.2016732119
DOI: http://dx.doi.org/10.1073/pnas.2016732119
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Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Citación
Song, Chen; Boly, Melanie; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Tononi, Giulio; fMRI spectral signatures of sleep; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 119; 30; 7-2022; 1-12
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