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dc.contributor.author
Noris, Patrizia
dc.contributor.author
Biino, Ginevra
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Pecci, Alessandro
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Civaschi, Elisa
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Savoia, Anna
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Seri, Marco
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Melazzini, Federica
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Loffreddo, Giuseppe
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Russo, Giovana
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Bozzi, Valeria
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Notarangelo, Lucia Dora
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Gresele, Paolo
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Heller, Paula Graciela
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Pujol Moix, Nuria
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Kunishima, Shinji
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Cattaneo, Marco
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Bussel, James
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de Candia, Erica
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Cagioni, Claudia
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Ramenghi, Ugo
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Barozzi, Serena
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Fabris, Fabrizio
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Balduini, Carlo L.
dc.date.available
2017-07-28T16:07:47Z
dc.date.issued
2014-08
dc.identifier.citation
Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-10
dc.identifier.issn
0006-4971
dc.identifier.uri
http://hdl.handle.net/11336/21509
dc.description.abstract
Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Hematology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Plaquetas
dc.subject
Trombocitopenias
dc.subject
Dpm
dc.subject.classification
Hematología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-13T17:23:10Z
dc.identifier.eissn
1528-0020
dc.journal.volume
124
dc.journal.number
6
dc.journal.pagination
4-10
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington D. C.
dc.description.fil
Fil: Noris, Patrizia. University of Pavia; Italia
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Fil: Biino, Ginevra. Consiglio Nazionale Delle Ricerche. Istituto di Genetica Molecolare; Italia
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Fil: Pecci, Alessandro. University of Pavia; Italia
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Fil: Civaschi, Elisa. University of Pavia; Italia
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Fil: Savoia, Anna. Università degli Studi di Trieste; Italia. Istituto Di Ricovero e Cura a Carattere Scientifico Burlo Garofolo; Italia
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Fil: Seri, Marco. Università di Bologna; Italia
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Fil: Melazzini, Federica. University of Pavia; Italia
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Fil: Loffreddo, Giuseppe. Pausilipon Hospital; Italia
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Fil: Russo, Giovana. Università degli Studi di Catania; Italia
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Fil: Bozzi, Valeria. University of Pavia; Italia
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Fil: Notarangelo, Lucia Dora. Spedali Civili. Ospedale dei Bambini; Italia
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Fil: Gresele, Paolo. Università di Perugia; Italia
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Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
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Fil: Pujol Moix, Nuria. Universitat Autònoma de Barcelona; España
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Fil: Kunishima, Shinji. National Hospital Organization Nagoya Medical Center; Japón
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Fil: Cattaneo, Marco. Università degli Studi di Milano; Italia
dc.description.fil
Fil: Bussel, James. Cornell University; Estados Unidos
dc.description.fil
Fil: de Candia, Erica. Universita Cattolica del Sacro Cuore; Italia
dc.description.fil
Fil: Cagioni, Claudia. University of Pavia; Italia
dc.description.fil
Fil: Ramenghi, Ugo. Università di Torino; Italia
dc.description.fil
Fil: Barozzi, Serena. University of Pavia; Italia
dc.description.fil
Fil: Fabris, Fabrizio. Università di Padova; Italia
dc.description.fil
Fil: Balduini, Carlo L.. University of Pavia; Italia
dc.journal.title
Blood
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1182/blood-2014-03-564328
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/124/6/e4?sso-checked=true
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126341/


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