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Artículo

Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders

Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; Seri, Marco; Melazzini, Federica; Loffreddo, Giuseppe; Russo, Giovana; Bozzi, Valeria; Notarangelo, Lucia Dora; Gresele, PaoloIcon ; Heller, Paula GracielaIcon ; Pujol Moix, Nuria; Kunishima, Shinji; Cattaneo, Marco; Bussel, James; de Candia, Erica; Cagioni, Claudia; Ramenghi, Ugo; Barozzi, Serena; Fabris, Fabrizio; Balduini, Carlo L.
Fecha de publicación: 08/2014
Editorial: American Society of Hematology
Revista: Blood
ISSN: 0006-4971
e-ISSN: 1528-0020
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Hematología

Resumen

Abnormalities of platelet size are one of the distinguishing features of inherited thrombocytopenias (ITs), and evaluation of blood films is recommended as an essential step for differential diagnosis of these disorders. Nevertheless, what we presently know about this subject is derived mainly from anecdotal evidence. To improve knowledge in this field, we evaluated platelet size on blood films obtained from 376 patients with all 19 forms of IT identified so far and found that these conditions differ not only in mean platelet diameter, but also in platelet diameter distribution width and the percentage of platelets with increased or reduced diameters. On the basis of these findings, we propose a new classification of ITs according to platelet size. It distinguishes forms with giant platelets, with large platelets, with normal or slightly increased platelet size, and with normal or slightly decreased platelet size. We also measured platelet diameters in 87 patients with immune thrombocytopenia and identified cutoff values for mean platelet diameter and the percentage of platelets with increased or reduced size that have good diagnostic accuracy in differentiating ITs with giant platelets and with normal or slightly decreased platelet size from immune thrombocytopenia and all other forms of IT.
Palabras clave: Plaquetas , Trombocitopenias , Dpm
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/21509
DOI: http://dx.doi.org/10.1182/blood-2014-03-564328
URL: http://www.bloodjournal.org/content/124/6/e4?sso-checked=true
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Articulos de INST.DE INVEST.MEDICAS
Citación
Noris, Patrizia; Biino, Ginevra; Pecci, Alessandro; Civaschi, Elisa; Savoia, Anna; et al.; Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders; American Society of Hematology; Blood; 124; 6; 8-2014; 4-10
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