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dc.contributor.author
Deeks, Steven G.
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Archin, Nancie
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Cannon, Paula
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Collins, Simon
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Jones, R. Brad
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de Jong, Marein A. W. P.
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Lambotte, Olivier
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Lamplough, Rosanne
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Ndung’u, Thumbi
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Sugarman, Jeremy
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Tiemessen, Caroline T.
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Vandekerckhove, Linos
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Lewin, Sharon R.
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Deeks, Steven
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de Jong, Marein
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Ndhlovu, Zaza
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Chomont, Nicolas
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Brumme, Zabrina
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Deng, Kai
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Jasenosky, Luke
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Jefferys, Richard
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Orta Resendiz, Aurelio
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Mardarelli, Frank
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Nijhuis, Monique
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Bar, Katharine
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Howell, Bonnie
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Schneider, Alex
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Turk, Gabriela Julia Ana
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Nabatanzi, Rose
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Blankson, Joel
dc.date.available
2023-09-28T12:19:36Z
dc.date.issued
2021-12
dc.identifier.citation
Deeks, Steven G.; Archin, Nancie; Cannon, Paula; Collins, Simon; Jones, R. Brad; et al.; Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021; Nature Publishing Group; Nature Medicine; 27; 12; 12-2021; 2085-2098
dc.identifier.issn
1078-8956
dc.identifier.uri
http://hdl.handle.net/11336/213424
dc.description.abstract
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combination of immune activators, neutralizing antibodies, and therapeutic vaccines, some nonhuman primate models have been cured, providing optimism for these approaches now being evaluated in human clinical trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect cells from infection, also holds promise for future HIV cure strategies. In this Review, we discuss advances related to HIV cure in the last 5 years, highlight remaining knowledge gaps and identify priority areas for research for the next 5 years.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HIV
dc.subject
Cura
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Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-21T11:19:45Z
dc.identifier.eissn
1546-170X
dc.journal.volume
27
dc.journal.number
12
dc.journal.pagination
2085-2098
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Deeks, Steven G.. University of California; Estados Unidos
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Fil: Archin, Nancie. University of North Carolina; Estados Unidos
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Fil: Cannon, Paula. University of Southern California; Estados Unidos
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Fil: Collins, Simon. Hiv I-base; Reino Unido
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Fil: Jones, R. Brad. Cornell University; Estados Unidos
dc.description.fil
Fil: de Jong, Marein A. W. P.. Aidsfonds; Países Bajos
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Fil: Lambotte, Olivier. Universite Paris-Saclay;
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Fil: Lamplough, Rosanne. International AIDS Society; Suiza
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Fil: Ndung’u, Thumbi. University College London; Estados Unidos. Ragon Institute of MGH; Estados Unidos. University of KwaZulu-Natal; Sudáfrica
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Fil: Sugarman, Jeremy. University Johns Hopkins; Estados Unidos
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Fil: Tiemessen, Caroline T.. University of the Witwatersrand; Sudáfrica
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Fil: Vandekerckhove, Linos. University of Ghent; Bélgica
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Fil: Lewin, Sharon R.. The Peter Doherty Institute For Infection And Immunity; Australia. Monash University; Australia. University of Melbourne; Australia
dc.description.fil
Fil: Deeks, Steven. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: de Jong, Marein. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Ndhlovu, Zaza. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Chomont, Nicolas. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Brumme, Zabrina. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Deng, Kai. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Jasenosky, Luke. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Jefferys, Richard. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Orta Resendiz, Aurelio. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Mardarelli, Frank. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Nijhuis, Monique. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Bar, Katharine. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Howell, Bonnie. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Schneider, Alex. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.description.fil
Fil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
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Fil: Nabatanzi, Rose. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
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Fil: Blankson, Joel. The International AIDS Society (IAS) Global Scientific Strategy working group; Estados Unidos
dc.journal.title
Nature Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41591-021-01590-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41591-021-01590-5
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