Artículo
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
Deeks, Steven G.; Archin, Nancie; Cannon, Paula; Collins, Simon; Jones, R. Brad; de Jong, Marein A. W. P.; Lambotte, Olivier; Lamplough, Rosanne; Ndung’u, Thumbi; Sugarman, Jeremy; Tiemessen, Caroline T.; Vandekerckhove, Linos; Lewin, Sharon R.; Deeks, Steven; de Jong, Marein; Ndhlovu, Zaza; Chomont, Nicolas; Brumme, Zabrina; Deng, Kai; Jasenosky, Luke; Jefferys, Richard; Orta Resendiz, Aurelio; Mardarelli, Frank; Nijhuis, Monique; Bar, Katharine; Howell, Bonnie; Schneider, Alex; Turk, Gabriela Julia Ana
; Nabatanzi, Rose; Blankson, Joel
Fecha de publicación:
12/2021
Editorial:
Nature Publishing Group
Revista:
Nature Medicine
ISSN:
1078-8956
e-ISSN:
1546-170X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combination of immune activators, neutralizing antibodies, and therapeutic vaccines, some nonhuman primate models have been cured, providing optimism for these approaches now being evaluated in human clinical trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect cells from infection, also holds promise for future HIV cure strategies. In this Review, we discuss advances related to HIV cure in the last 5 years, highlight remaining knowledge gaps and identify priority areas for research for the next 5 years.
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Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Citación
Deeks, Steven G.; Archin, Nancie; Cannon, Paula; Collins, Simon; Jones, R. Brad; et al.; Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021; Nature Publishing Group; Nature Medicine; 27; 12; 12-2021; 2085-2098
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