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dc.contributor.author
Keret, Ophir
dc.contributor.author
Staffaroni, Adam M.
dc.contributor.author
Ringman, John M.
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Cobigo, Yann
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Goh, Sheng Yang M.
dc.contributor.author
Wolf, Amy
dc.contributor.author
Allen, Isabel Elaine
dc.contributor.author
Salloway, Stephen
dc.contributor.author
Chhatwal, Jasmeer
dc.contributor.author
Brickman, Adam M.
dc.contributor.author
Reyes Dumeyer, Dolly
dc.contributor.author
Bateman, Randal J.
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Benzinger, Tammie L.S.
dc.contributor.author
Morris, John C.
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Ances, Beau M.
dc.contributor.author
Joseph Mathurin, Nelly
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Perrin, Richard J.
dc.contributor.author
Gordon, Brian A.
dc.contributor.author
Levin, Johannes
dc.contributor.author
Vöglein, Jonathan
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Jucker, Mathias
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la Fougère, Christian
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Martins, Ralph N.
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Sohrabi, Hamid R.
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Taddei, Kevin
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Villemagne, Victor L.
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Schofield, Peter R.
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Brooks, William S.
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Fulham, Michael
dc.contributor.author
Masters, Colin L.
dc.contributor.author
Allegri, Ricardo Francisco
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dc.date.available
2023-09-19T11:58:35Z
dc.date.issued
2021-06
dc.identifier.citation
Keret, Ophir; Staffaroni, Adam M.; Ringman, John M.; Cobigo, Yann; Goh, Sheng Yang M.; et al.; Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease; John Wiley & Sons; Alzheimers & Dementia; 13; 1; 6-2021; 1-11
dc.identifier.issn
1552-5260
dc.identifier.uri
http://hdl.handle.net/11336/211950
dc.description.abstract
Introduction: Asymptomatic and mildly symptomatic dominantly inherited Alzheimer's disease mutation carriers (DIAD-MC) are ideal candidates for preventative treatment trials aimed at delaying or preventing dementia onset. Brain atrophy is an early feature of DIAD-MC and could help predict risk for dementia during trial enrollment. Methods: We created a dementia risk score by entering standardized gray-matter volumes from 231 DIAD-MC into a logistic regression to classify participants with and without dementia. The score's predictive utility was assessed using Cox models and receiver operating curves on a separate group of 65 DIAD-MC followed longitudinally. Results: Our risk score separated asymptomatic versus demented DIAD-MC with 96.4% (standard error = 0.02) and predicted conversion to dementia at next visit (hazard ratio = 1.32, 95% confidence interval [CI: 1.15, 1.49]) and within 2 years (area under the curve = 90.3%, 95% CI [82.3%–98.2%]) and improved prediction beyond established methods based on familial age of onset. Discussion: Individualized risk scores based on brain atrophy could be useful for establishing enrollment criteria and stratifying DIAD-MC participants for prevention trials.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE
dc.subject
BRAIN ATROPHY
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DOMINANTLY INHERITED ALZHEIMER NETWORK
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PRECLINICAL ALZHEIMER'S DISEASE
dc.subject.classification
Neurología Clínica
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dc.subject.classification
Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-18T13:29:01Z
dc.identifier.eissn
2352-8729
dc.journal.volume
13
dc.journal.number
1
dc.journal.pagination
1-11
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva Jersey
dc.description.fil
Fil: Keret, Ophir. University of California; Estados Unidos
dc.description.fil
Fil: Staffaroni, Adam M.. University of California; Estados Unidos
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Fil: Ringman, John M.. University of Southern California; Estados Unidos
dc.description.fil
Fil: Cobigo, Yann. University of California; Estados Unidos
dc.description.fil
Fil: Goh, Sheng Yang M.. University of California; Estados Unidos
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Fil: Wolf, Amy. University of California; Estados Unidos
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Fil: Allen, Isabel Elaine. University of California; Estados Unidos
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Fil: Salloway, Stephen. Brown University; Estados Unidos
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Fil: Chhatwal, Jasmeer. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Brickman, Adam M.. Columbia University; Estados Unidos
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Fil: Reyes Dumeyer, Dolly. Columbia University; Estados Unidos
dc.description.fil
Fil: Bateman, Randal J.. University of Washington; Estados Unidos
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Fil: Benzinger, Tammie L.S.. University of Washington; Estados Unidos
dc.description.fil
Fil: Morris, John C.. University of Washington; Estados Unidos
dc.description.fil
Fil: Ances, Beau M.. University of Washington; Estados Unidos
dc.description.fil
Fil: Joseph Mathurin, Nelly. University of Washington; Estados Unidos
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Fil: Perrin, Richard J.. University of Washington; Estados Unidos
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Fil: Gordon, Brian A.. University of Washington; Estados Unidos
dc.description.fil
Fil: Levin, Johannes. German Center for Neurodegenerative Diseases; Alemania. Ludwig Maximilians Universitat; Alemania
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Fil: Vöglein, Jonathan. Ludwig Maximilians Universitat; Alemania. German Center for Neurodegenerative Diseases; Alemania
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Fil: Jucker, Mathias. German Center for Neurodegenerative Diseases; Alemania. Eberhard Karls Universität Tübingen; Alemania
dc.description.fil
Fil: la Fougère, Christian. Eberhard Karls Universität Tübingen; Alemania. German Center for Neurodegenerative Diseases; Alemania
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Fil: Martins, Ralph N.. Cooperative Research Centres Australia; Australia. University of Western Australia; Australia. Edith Cowan University; Australia. Australian Alzheimer's Research Foundation; Australia. Macquarie University; Australia
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Fil: Sohrabi, Hamid R.. University of Western Australia; Australia. Macquarie University; Australia. Australian Alzheimer's Research Foundation; Australia. Cooperative Research Centres Australia; Australia. Edith Cowan University; Australia
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Fil: Taddei, Kevin. Australian Alzheimer's Research Foundation; Australia. Edith Cowan University; Australia
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Fil: Villemagne, Victor L.. Austin Health; Australia
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Fil: Schofield, Peter R.. Neuroscience Research Australia; Australia. Unsw Medicine; Australia
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Fil: Brooks, William S.. Neuroscience Research Australia; Australia. Unsw Medicine; Australia
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Fil: Fulham, Michael. Royal Prince Alfred Hospital; Australia
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Fil: Masters, Colin L.. University of Melbourne; Australia
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Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
dc.journal.title
Alzheimers & Dementia
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/dad2.12197
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12197
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