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dc.contributor.author
Marques Ventura, Ana Lucia
dc.contributor.author
dos Santos Rodrigues, Alexandre
dc.contributor.author
Mitchell, Claire H.
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Faillace, Maria Paula
dc.date.available
2023-09-13T14:01:04Z
dc.date.issued
2019-09
dc.identifier.citation
Marques Ventura, Ana Lucia; dos Santos Rodrigues, Alexandre; Mitchell, Claire H.; Faillace, Maria Paula; Purinergic signaling in the retina: From development to disease; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 151; 9-2019; 92-108
dc.identifier.issn
0361-9230
dc.identifier.uri
http://hdl.handle.net/11336/211362
dc.description.abstract
Retinal injuries and diseases are major causes of human disability involving vision impairment by the progressive and permanent loss of retinal neurons. During development, assembly of this tissue entails a successive and overlapping, signal-regulated engagement of complex events that include proliferation of progenitors, neurogenesis, cell death, neurochemical differentiation and synaptogenesis. During retinal damage, several of these events are re-activated with both protective and detrimental consequences. Purines and pyrimidines, along with their metabolites are emerging as important molecules regulating both retinal development and the tissue's responses to damage. The present review provides an overview of the purinergic signaling in the developing and injured retina. Recent findings on the presence of vesicular and channel-mediated ATP release by retinal and retinal pigment epithelial cells, adenosine synthesis and release, expression of receptors and intracellular signaling pathways activated by purinergic signaling in retinal cells are reported. The pathways by which purinergic receptors modulate retinal cell proliferation, migration and death of retinal cells during development and injury are summarized. The contribution of nucleotides to the self-repair of the injured zebrafish retina is also discussed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ATP
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ADENOSINE
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NUCLEOTIDES
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P1 RECEPTORS
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P2 RECEPTORS
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RETINA DISEASES
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Purinergic signaling in the retina: From development to disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-12T18:06:46Z
dc.journal.volume
151
dc.journal.pagination
92-108
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Marques Ventura, Ana Lucia. Universidade Federal Fluminense; Brasil
dc.description.fil
Fil: dos Santos Rodrigues, Alexandre. Universidade Federal Fluminense; Brasil
dc.description.fil
Fil: Mitchell, Claire H.. University of Pennsylvania; Estados Unidos
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Fil: Faillace, Maria Paula. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.journal.title
Brain Research Bulletin
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0361923018305379
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.brainresbull.2018.10.016
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