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Artículo

Purinergic signaling in the retina: From development to disease

Marques Ventura, Ana Lucia; dos Santos Rodrigues, Alexandre; Mitchell, Claire H.; Faillace, Maria PaulaIcon
Fecha de publicación: 09/2019
Editorial: Pergamon-Elsevier Science Ltd
Revista: Brain Research Bulletin
ISSN: 0361-9230
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Retinal injuries and diseases are major causes of human disability involving vision impairment by the progressive and permanent loss of retinal neurons. During development, assembly of this tissue entails a successive and overlapping, signal-regulated engagement of complex events that include proliferation of progenitors, neurogenesis, cell death, neurochemical differentiation and synaptogenesis. During retinal damage, several of these events are re-activated with both protective and detrimental consequences. Purines and pyrimidines, along with their metabolites are emerging as important molecules regulating both retinal development and the tissue's responses to damage. The present review provides an overview of the purinergic signaling in the developing and injured retina. Recent findings on the presence of vesicular and channel-mediated ATP release by retinal and retinal pigment epithelial cells, adenosine synthesis and release, expression of receptors and intracellular signaling pathways activated by purinergic signaling in retinal cells are reported. The pathways by which purinergic receptors modulate retinal cell proliferation, migration and death of retinal cells during development and injury are summarized. The contribution of nucleotides to the self-repair of the injured zebrafish retina is also discussed.
Palabras clave: ATP , ADENOSINE , NUCLEOTIDES , P1 RECEPTORS , P2 RECEPTORS , RETINA DISEASES
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/211362
URL: https://www.sciencedirect.com/science/article/pii/S0361923018305379
DOI: http://dx.doi.org/10.1016/j.brainresbull.2018.10.016
Colecciones
Articulos(IFIBIO HOUSSAY)
Articulos de INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY
Citación
Marques Ventura, Ana Lucia; dos Santos Rodrigues, Alexandre; Mitchell, Claire H.; Faillace, Maria Paula; Purinergic signaling in the retina: From development to disease; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 151; 9-2019; 92-108
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