Artículo
Assessment on Different Vaccine Formulation Parameters in the Protection against Heterologous Challenge with FMDV in Cattle
Di Giacomo, Sebastián Víctor; Bucafusco, Danilo
; Schammas, Juan Manuel; Pega, Juan Franco
; Miraglia, Maria Cruz
; Barrionuevo, Florencia Mariel
; Capozzo, Alejandra Victoria
; Pérez Filgueira, Daniel Mariano
Fecha de publicación:
08/2022
Editorial:
MDPI
Revista:
Viruses
ISSN:
1999-4915
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting severe damage to the international trade and livestock industry. FMDV antigenic variability remains one of the biggest challenges for vaccine-based control strategies. The current study analyzed the host’s adaptive immune responses in cattle immunized with different vaccine protocols and investigated its associations with the clinical outcome after infection with a heterologous strain of FMDV. The results showed that antigenic payload, multivalency, and revaccination may impact on the clinical outcome after heterologous challenge with FMDV. Protection from the experimental infection was related to qualitative traits of the elicited antibodies, such as avidity, IgG isotype composition, and specificity diversity, modulating and reflecting the vaccine-induced maturation of the humoral response. The correlation analyses of the serum avidity obtained per vaccinated individual might suggest that conventional vaccination can induce high-affinity immunoglobulins against conserved epitopes even within different FMDV serotypes. Cross-reaction among strains by these high-affinity antibodies may support further protection against a heterologous infection with FMDV.
Palabras clave:
CATTLE
,
FMDV
,
HETEROLOGOUS PROTECTION
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos (ICYTESAS)
Articulos de INSTITUTO DE INVESTIGACION DE LA CADENA LACTEA
Articulos de INSTITUTO DE INVESTIGACION DE LA CADENA LACTEA
Articulos (IVIT)
Articulos de INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Articulos de INSTITUTO DE VIROLOGIA E INNOVACIONES TECNOLOGICAS
Citación
Di Giacomo, Sebastián Víctor; Bucafusco, Danilo; Schammas, Juan Manuel; Pega, Juan Franco; Miraglia, Maria Cruz; et al.; Assessment on Different Vaccine Formulation Parameters in the Protection against Heterologous Challenge with FMDV in Cattle; MDPI; Viruses; 14; 8; 8-2022; 1-18
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