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dc.contributor.author
Hirata, Tsutomu
dc.contributor.author
Li, Peijun
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Lanuza, Guillermo Marcos
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Cocas, Laura A.
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Huntsman, Molly M.
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Corbin, Joshua G.
dc.date.available
2017-07-17T21:00:27Z
dc.date.issued
2009-02
dc.identifier.citation
Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-149
dc.identifier.issn
1097-6256
dc.identifier.uri
http://hdl.handle.net/11336/20755
dc.description.abstract
The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Amigdala
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Development
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Transcription Factor
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Thelencephalon
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-11T19:28:39Z
dc.identifier.eissn
1546-1726
dc.journal.volume
12
dc.journal.number
2
dc.journal.pagination
141-149
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Hirata, Tsutomu. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos
dc.description.fil
Fil: Li, Peijun. University Of Georgetown; Estados Unidos
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Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Cocas, Laura A.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos. University Of Georgetown; Estados Unidos
dc.description.fil
Fil: Huntsman, Molly M.. University Of Georgetown; Estados Unidos
dc.description.fil
Fil: Corbin, Joshua G.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos
dc.journal.title
Nature Neuroscience.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/neuro/journal/v12/n2/full/nn.2241.html
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nn.2241
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