Artículo
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos
; Cocas, Laura A.; Huntsman, Molly M.; Corbin, Joshua G.
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Fecha de publicación:
02/2009
Editorial:
Nature Publishing Group
Revista:
Nature Neuroscience.
ISSN:
1097-6256
e-ISSN:
1546-1726
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.
Palabras clave:
Amigdala
,
Development
,
Transcription Factor
,
Thelencephalon
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-149
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