Artículo
Canonical phospholipase D isoforms in visual function and ocular response to stress
Fecha de publicación:
04/2022
Editorial:
Academic Press Ltd - Elsevier Science Ltd
Revista:
Experimental Eye Research
ISSN:
0014-4835
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG). Through the generation of these lipid messengers, the PLD pathway can modulate several cellular events, such as proliferation, membrane trafficking, autophagy and the inflammatory response, among many others. This review summarizes the participation of canonical PLD isoforms in physiological and pathological responses in the eye. Although the role of the PLD pathway in ocular and retinal response to stress has not been fully elucidated, pharmacological inhibition of these signaling enzymes seems to be a promising therapeutic tool to avoid inflammatory processes in the retina, abnormal cellular proliferation on the ocular surface and pathological neovascularization. On the contrary, the modulation of classical PLDs may potentiate corneal healing. In summary, the knowledge of the role of PLD1 and PLD2 in the molecular basis of ocular inflammatory and degenerative diseases opens new avenues for potential therapeutic exploration.
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Articulos(INIBIBB)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
Bermúdez, Vicente; Tenconi, Paula Estefania; Giusto, Norma Maria; Mateos, Melina Valeria; Canonical phospholipase D isoforms in visual function and ocular response to stress; Academic Press Ltd - Elsevier Science Ltd; Experimental Eye Research; 217; 108976; 4-2022; 1-8
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