Artículo
Structural and evolutionary analysis unveil functional adaptations in the promiscuous behavior of serum albumins
Velez Rueda, Ana Julia
; Benítez, Guillermo Ignacio
; Sommese, Leandro Matías
; Ardanaz, Sebastián Mario
; Borucki, Estefanía Lorena
; Palopoli, Nicolás
; Iglesias, Luis Emilio
; Parisi, Gustavo Daniel
Fecha de publicación:
06/2022
Editorial:
Elsevier France-Editions Scientifiques Medicales Elsevier
Revista:
Biochimie
ISSN:
0300-9084
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Promiscuous activities have been related to the capacity to catalyze reactions different from those a protein has evolved to sustain. In this work, we rethought the serum albumin's promiscuous behavior using evolutionary and structural analysis. We found that the cross aldol condensation of acetone and p-formylbenzonitrile is a promiscuous reaction conserved in humans serum albumin and in closely related albumins from other mammals. Evolutionary analysis indicates that the residues involved in this promiscuous reaction are evolving under positive selection, an evolutionary pattern indicating a putative functional adaptation. Also, key residues are located in an evolutionary conserved cavity connected with the protein surface with an also conserved tunnel and mutations involving these residues are described in human diseases. Overall, our results suggest that albumin could have evolved to sustain a still unknown biological function among the many others it maintains. Our results could contribute to better characterize the serum albumin family and raise questions about the evolution of protein promiscuity and function.
Palabras clave:
CATALYTIC ACTIVITY
,
PROMISCUITY
,
SEROALBUMIN
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Velez Rueda, Ana Julia; Benítez, Guillermo Ignacio; Sommese, Leandro Matías; Ardanaz, Sebastián Mario; Borucki, Estefanía Lorena; et al.; Structural and evolutionary analysis unveil functional adaptations in the promiscuous behavior of serum albumins; Elsevier France-Editions Scientifiques Medicales Elsevier; Biochimie; 197; 6-2022; 113-120
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