Mostrar el registro sencillo del ítem
dc.contributor.author
Echave, Julian
dc.contributor.author
Wilke, Claus O.
dc.date.available
2023-06-07T02:32:19Z
dc.date.issued
2017-05
dc.identifier.citation
Echave, Julian; Wilke, Claus O.; Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence; Annual Reviews; Annual Review Of Biophysics; 46; 5-2017; 85-103
dc.identifier.issn
1936-122X
dc.identifier.uri
http://hdl.handle.net/11336/199789
dc.description.abstract
For decades, rates of protein evolution have been interpreted in terms of the vague concept of “functional importance”. Slowly evolving proteins or sites within proteins were assumed to be more functionally important and thus subject to stronger selection pressure. More recently, biophysical models of protein evolution, which combine evolutionary theory with protein biophysics, have completely revolutionized our view of the forces that shape sequence divergence. Slowly evolving proteins have been found to evolve slowly because of selection against toxic mis-folding and misinteractions, linking their rate of evolution primarily to their abundance. Similarly, most slowly evolving sites in proteins are not directly involved in function, but mutating them has large impacts on protein structure and stability. Here, we review the studies of the emergent field of biophysical protein evolution that have shaped our current understanding of sequence divergence patterns. We also propose future research directions to develop this nascent field.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Annual Reviews
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EVOLUTIONARY RATE
dc.subject
FITNESS LANDSCAPE
dc.subject
PROTEIN FOLDING
dc.subject
PROTEIN MISFOLDING
dc.subject
PROTEIN-PROTEIN INTERACTION
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-06T12:36:25Z
dc.identifier.eissn
1936-1238
dc.journal.volume
46
dc.journal.pagination
85-103
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Palo Alto
dc.description.fil
Fil: Echave, Julian. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Wilke, Claus O.. University of Texas at Austin; Estados Unidos
dc.journal.title
Annual Review Of Biophysics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.annualreviews.org/doi/10.1146/annurev-biophys-070816-033819
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1146/annurev-biophys-070816-033819
Archivos asociados