Artículo
Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence
Fecha de publicación:
05/2017
Editorial:
Annual Reviews
Revista:
Annual Review Of Biophysics
ISSN:
1936-122X
e-ISSN:
1936-1238
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
For decades, rates of protein evolution have been interpreted in terms of the vague concept of “functional importance”. Slowly evolving proteins or sites within proteins were assumed to be more functionally important and thus subject to stronger selection pressure. More recently, biophysical models of protein evolution, which combine evolutionary theory with protein biophysics, have completely revolutionized our view of the forces that shape sequence divergence. Slowly evolving proteins have been found to evolve slowly because of selection against toxic mis-folding and misinteractions, linking their rate of evolution primarily to their abundance. Similarly, most slowly evolving sites in proteins are not directly involved in function, but mutating them has large impacts on protein structure and stability. Here, we review the studies of the emergent field of biophysical protein evolution that have shaped our current understanding of sequence divergence patterns. We also propose future research directions to develop this nascent field.
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Articulos de SEDE CENTRAL
Citación
Echave, Julian; Wilke, Claus O.; Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence; Annual Reviews; Annual Review Of Biophysics; 46; 5-2017; 85-103
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