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dc.contributor.author
Rodriguez, Alfredo E.
dc.contributor.author
Vigo, Cesar F.
dc.contributor.author
Delacasa, Alejandro
dc.contributor.author
Mieres, Juan
dc.contributor.author
Fernandez Pereira, Carlos
dc.contributor.author
Bernardi, Victor
dc.contributor.author
Bettinoti, Marcelo
dc.contributor.author
Rodriguez Granillo, Gaston Alfredo
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dc.contributor.author
Curotto, Valeria
dc.contributor.author
Rubilar, Bibiana
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Tronge, Jorge
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Palacios, Igor F.
dc.contributor.author
Antoniucci, David
dc.date.available
2023-05-22T13:05:19Z
dc.date.issued
2011-02
dc.identifier.citation
Rodriguez, Alfredo E.; Vigo, Cesar F.; Delacasa, Alejandro; Mieres, Juan; Fernandez Pereira, Carlos; et al.; Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial; Wiley-liss, div John Wiley & Sons Inc.; Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions.; 77; 3; 2-2011; 335-342
dc.identifier.issn
1522-1946
dc.identifier.uri
http://hdl.handle.net/11336/198331
dc.description.abstract
Objectives: The aim of this study was the comparison of a new double-coated paclitaxel-eluting coronary stent with bare-metal stent (BMS) in patients undergoing percutaneous coronary intervention. Background: Stent coating with biodegradable polymers as a platform for elution of drugs has the potential for complete elution of drugs and for decreasing the risk of late complications. Methods: Multicenter randomized trial comparing a paclitaxel-eluting stent (PES) coated with a biodegradable polymer and glycocalyx with the equivalent BMS. We randomly assigned 422 patients with de novo coronary lesions to PES (211 patients) or to BMS (211 patients). Primary end point was target vessel failure (TVF) defined as cardiac death, myocardial infarction, and target vessel revascularization. Clinical secondary end points were target vessel revascularization, target lesion revascularization, stent thrombosis (ST), and major adverse cardiovascular events (MACE). Angiographic secondary end points were late loss and binary restenosis. Results: At 1 year of follow-up, TVF rate was 9.5% in the PES group and 17.1% in the BMS group (P = 0.02), and MACE rate was 10% in PES and 19% in BMS arm (P = 0.009). All other secondary end points were reached but ST. ST rate was low and similar in both study arms. Conclusions: The study shows that patients treated with PES with dual coating technology had significantly lower incidence of TVF and MACE than those treated with BMS design; however, longer follow-up should be necessary to assess true advantages of this technology compared with the previous one.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACUTE CORONARY SYNDROME (ACS)
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DRUG DELIVERY (DDEL)
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PERCUTANEOUS CORONARY INTERVENTION (PCI)
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QUANTITATIVE CORONARY ANGIOGRAPHY (QCA)
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RESTENOSIS (RSTN)
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Efficacy and safety of a double-coated paclitaxel-eluting coronary stent: The EUCATAX trial
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-05-22T11:56:56Z
dc.journal.volume
77
dc.journal.number
3
dc.journal.pagination
335-342
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Rodriguez, Alfredo E.. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Vigo, Cesar F.. Sanatorio del Salvador S. A.; Argentina
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Fil: Delacasa, Alejandro. Sanatorio Belgrano; Argentina
dc.description.fil
Fil: Mieres, Juan. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Fernandez Pereira, Carlos. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Bernardi, Victor. Clinica del Sol;
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Fil: Bettinoti, Marcelo. Sanatorio Guemes Sociedad Anonima.; Argentina
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Sanatorio "Otamendi y Miroli S.A.". Servicio de Diagnóstico por Imágenes. Departamento de Imágenes en Cardiología. Centro de Investigaciones Cardiovasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Curotto, Valeria. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Rubilar, Bibiana. Sanatorio "Otamendi y Miroli S. A."; Argentina
dc.description.fil
Fil: Tronge, Jorge. No especifíca;
dc.description.fil
Fil: Palacios, Igor F.. Massachusetts General Hospital; Estados Unidos
dc.description.fil
Fil: Antoniucci, David. Careggi Hospital; Italia
dc.journal.title
Catheterization And Cardiovascular Interventions : Official Journal Of The Society For Cardiac Angiography & Interventions.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/ccd.22769
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ccd.22769
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