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dc.contributor.author
Ahmadian Chashmi, Najmeh  
dc.contributor.author
Sharifi, Mozafar  
dc.contributor.author
Yousefzadi, Morteza  
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Behmanesh, Mehrdad  
dc.contributor.author
Rezadoost, Hassan  
dc.contributor.author
Cardillo, Alejandra Beatriz  
dc.contributor.author
Palazon, Javier  
dc.date.available
2015-09-03T19:07:33Z  
dc.date.issued
2013-02  
dc.identifier.citation
Ahmadian Chashmi, Najmeh; Sharifi, Mozafar; Yousefzadi, Morteza; Behmanesh, Mehrdad; Rezadoost, Hassan; et al.; Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss; Birkhauser Boston Inc; Medicinal Chemistry Research; 22; 2; 2-2013; 745-752  
dc.identifier.issn
1054-2523  
dc.identifier.uri
http://hdl.handle.net/11336/1934  
dc.description.abstract
Linum album is a herbaceous medicinal plant that contains some lignans with antiviral and anticancer properties such as podophyllotoxin (PTOX) and 6-methoxy podophyllotoxin (MPTOX). In this research, hairy root cultures of L. album were established by transformation with Agrobacterium rhizogenes strains LBA9402, A4, AR15834 and A. tumefaciens strain C58C1 (pRiA4). The presence of PTOX and MPTOX in the hairy roots was verified by ESI/MS in positive ion mode. MPTOX was confirmed and its enantiomer determined by nuclear magnetic resonance spectroscopy and circular dichroism spectroscopy, respectively. PTOX and MPTOX production was determined by HPLC, in different lines of hairy roots. The results showed that all obtained hairy root lines produced higher yield of lignans than mother plant roots. In addition, the lignans content in the roots derived from A. rhizogenes strain LBA9402 was higher than in those obtained from A. tumefaciens strain C58C1.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Birkhauser Boston Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
6-METHOXY PODOPHYLLOTOXIN (MPTOX)  
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AGROBACTERIUM  
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HAIRY ROOTS  
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LINUM ALBUM  
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PODOPHYLLOTOXIN (PTOX)  
dc.subject.classification
Biología Celular, Microbiología  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
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Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.  
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Biotecnología Industrial  
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INGENIERÍAS Y TECNOLOGÍAS  
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Farmacología y Farmacia  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Analysis of 6-methoxy podophyllotoxin and podophyllotoxin in hairy root cultures of Linum album Kotschy ex Boiss  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-03-30 10:35:44.97925-03  
dc.identifier.eissn
1554-8120  
dc.journal.volume
22  
dc.journal.number
2  
dc.journal.pagination
745-752  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Ahmadian Chashmi, Najmeh. Tarbiat Modares University; Irán  
dc.description.fil
Fil: Sharifi, Mozafar. Tarbiat Modares University; Irán  
dc.description.fil
Fil: Yousefzadi, Morteza. Tarbiat Modares University; Irán  
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Fil: Behmanesh, Mehrdad. Tarbiat Modares University; Irán  
dc.description.fil
Fil: Rezadoost, Hassan. Shahid Beheshti University; Irán  
dc.description.fil
Fil: Cardillo, Alejandra Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina  
dc.description.fil
Fil: Palazon, Javier. Universidad de Barcelona. Facultad de Farmacia; España;  
dc.journal.title
Medicinal Chemistry Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00044-012-0067-1  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00044-012-0067-1  

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