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dc.contributor.author
Soloneski, Sonia Maria Elsa
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dc.contributor.author
Larramendy, Marcelo Luis
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dc.date.available
2023-04-10T13:49:41Z
dc.date.issued
2010-02
dc.identifier.citation
Soloneski, Sonia Maria Elsa; Larramendy, Marcelo Luis; Sister chromatid exchanges and chromosomal aberrations in Chinese Hamster Ovary (CHO-K1) cells treated with insecticide pirimicarb; Elsevier Science; Journal of Hazardous Materials; 174; 1-3; 2-2010; 410-415
dc.identifier.issn
0304-3894
dc.identifier.uri
http://hdl.handle.net/11336/193027
dc.description.abstract
Pirimicarb and its formulation Aficida® (50% pirimicarb) effects were studied on CHO-K1 cells employing sister chromatid exchange (SCE), chromosomal aberrations (CA), cell-cycle progression and mitotic index analyses. Continuous treatments were performed within 10-300 μg/ml concentration-range. Pirimicarb, but not Aficida®, induced a concentration-dependent increase of abnormal cells. Pirimicarb induced a greater frequency of chromatid/isochromatid breaks than Aficida® did. Regression analyses showed a concentration-dependent increase in the frequency of chromatid-type breaks for both compounds whereas only the frequency of isochromatid-type breaks did in those pirimicarb-treated cultures. SCEs in pirimicarb- or Aficida®-treated cultures were significantly higher than control values with concentrations of 100-200 μg/ml. Both test compounds induced equivalent frequency of SCEs. A delay in cell-cycle kinetics was observed for pirimicarb and Aficida® within 100-300 and 200-300 μg/ml concentration-range, respectively. An inhibition of MI was observed for both chemicals regardless of tested concentrations. Finally, the CAs appears to be a higher sensitive bioassay to detect DNA damage at lower concentrations of pirimicarb than SCEs does. The results demonstrated that pirimicarb and Aficida® exert geno-cytotoxicity, at least in CHO-K1 cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CARBAMATES
dc.subject
CYTOTOXICITY
dc.subject
GENOTOXICITY
dc.subject
MAMMALIAN CELL LINES
dc.subject
TECHNICAL FORMULATIONS
dc.subject.classification
Genética y Herencia
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Sister chromatid exchanges and chromosomal aberrations in Chinese Hamster Ovary (CHO-K1) cells treated with insecticide pirimicarb
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-04-10T10:23:03Z
dc.journal.volume
174
dc.journal.number
1-3
dc.journal.pagination
410-415
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Soloneski, Sonia Maria Elsa. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Laboratorio de Citogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Larramendy, Marcelo Luis. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Laboratorio de Citogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Journal of Hazardous Materials
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304389409015295
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jhazmat.2009.09.068
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