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dc.contributor.author
Ripoll, Giselle Vanina
dc.contributor.author
Garona, Juan
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Hermo, Guillermo Adrian
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Gomez, Daniel Eduardo
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Alonso, Daniel Fernando
dc.date.available
2023-04-03T19:37:24Z
dc.date.issued
2010-12
dc.identifier.citation
Ripoll, Giselle Vanina; Garona, Juan; Hermo, Guillermo Adrian; Gomez, Daniel Eduardo; Alonso, Daniel Fernando; Effects of the synthetic vasopressin analog desmopressin in a mouse model of colon cancer; Int Inst Anticancer Research; Anticancer Research; 30; 12; 12-2010; 5049-5054
dc.identifier.issn
0250-7005
dc.identifier.uri
http://hdl.handle.net/11336/192563
dc.description.abstract
Experimental and clinical data indicated that perioperative administration of the hemostatic peptide desmopressin (DDAVP) can inhibit progression of residual metastatic cells. The compound seems to act by inducing an agonist effect on specific V2 vasopressin membrane receptors present in both tumor cells and endothelial cells. Here we explored the antitumor effects of DDAVP in cultured colon carcinoma cells and in a syngeneic Balb/c mouse model. Both human Colo-205 and mouse CT-26 colon carcinoma cell lines expressed the V2 receptor, as revealed by immunofluorescence. DDAVP (at doses ranging from 100 ng/ml to 1 μg/ml) exerted a modest but significant antiproliferative effect on cultured CT26 and Colo-205 cells. In vivo, DDAVP (2 intravenous doses of 2 μg/kg) reduced accumulation of ascites and formation of intestinal tumor nodules in mice intraperitoneally inoculated with CT-26 cells. Perioperative administration of DDAVP significantly inhibited tumor progression in animals surgically implanted in the spleen with CT-26 cells, and caused some reduction in liver metastasis. Although DDAVP and 5- fluorouracil demonstrated additive cytostatic effects in vitro, no antitumor effects were observed in this study in mice receiving a single cycle of chemotherapy (25 mg/kg) in combination with the peptide. Our data suggest that DDAVP may be potentially used to minimize spread or survival of residual malignant cells during surgical procedures for colon and other gastrointestinal tumors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Int Inst Anticancer Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DESMOPRESSIN
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COLON CANCER
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effects of the synthetic vasopressin analog desmopressin in a mouse model of colon cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-23T12:23:43Z
dc.identifier.eissn
1791-7530
dc.journal.volume
30
dc.journal.number
12
dc.journal.pagination
5049-5054
dc.journal.pais
Grecia
dc.description.fil
Fil: Ripoll, Giselle Vanina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Garona, Juan. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hermo, Guillermo Adrian. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gomez, Daniel Eduardo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Anticancer Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://ar.iiarjournals.org/content/30/12/5049
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