Artículo
Effects of the synthetic vasopressin analog desmopressin in a mouse model of colon cancer
Ripoll, Giselle Vanina
; Garona, Juan
; Hermo, Guillermo Adrian
; Gomez, Daniel Eduardo
; Alonso, Daniel Fernando
Fecha de publicación:
12/2010
Editorial:
Int Inst Anticancer Research
Revista:
Anticancer Research
ISSN:
0250-7005
e-ISSN:
1791-7530
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Experimental and clinical data indicated that perioperative administration of the hemostatic peptide desmopressin (DDAVP) can inhibit progression of residual metastatic cells. The compound seems to act by inducing an agonist effect on specific V2 vasopressin membrane receptors present in both tumor cells and endothelial cells. Here we explored the antitumor effects of DDAVP in cultured colon carcinoma cells and in a syngeneic Balb/c mouse model. Both human Colo-205 and mouse CT-26 colon carcinoma cell lines expressed the V2 receptor, as revealed by immunofluorescence. DDAVP (at doses ranging from 100 ng/ml to 1 μg/ml) exerted a modest but significant antiproliferative effect on cultured CT26 and Colo-205 cells. In vivo, DDAVP (2 intravenous doses of 2 μg/kg) reduced accumulation of ascites and formation of intestinal tumor nodules in mice intraperitoneally inoculated with CT-26 cells. Perioperative administration of DDAVP significantly inhibited tumor progression in animals surgically implanted in the spleen with CT-26 cells, and caused some reduction in liver metastasis. Although DDAVP and 5- fluorouracil demonstrated additive cytostatic effects in vitro, no antitumor effects were observed in this study in mice receiving a single cycle of chemotherapy (25 mg/kg) in combination with the peptide. Our data suggest that DDAVP may be potentially used to minimize spread or survival of residual malignant cells during surgical procedures for colon and other gastrointestinal tumors.
Palabras clave:
DESMOPRESSIN
,
COLON CANCER
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Ripoll, Giselle Vanina; Garona, Juan; Hermo, Guillermo Adrian; Gomez, Daniel Eduardo; Alonso, Daniel Fernando; Effects of the synthetic vasopressin analog desmopressin in a mouse model of colon cancer; Int Inst Anticancer Research; Anticancer Research; 30; 12; 12-2010; 5049-5054
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