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dc.contributor.author
Nemeth, Katie M.
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Federico, Sara
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Carcaboso, Angel M.
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Shen, Ying
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Schaiquevich, Paula Susana
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Zhang, Jiakun
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Egorin, Merrill
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Stewart, Clinton
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Dyer, Michael A.
dc.date.available
2023-03-23T18:00:49Z
dc.date.issued
2011-01
dc.identifier.citation
Nemeth, Katie M.; Federico, Sara; Carcaboso, Angel M.; Shen, Ying; Schaiquevich, Paula Susana; et al.; Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma; John Wiley & Sons; Cancer; 117; 2; 1-2011; 421-434
dc.identifier.issn
0008-543X
dc.identifier.uri
http://hdl.handle.net/11336/191642
dc.description.abstract
The authors demonstrated previously that the combination of topotecan (TPT) and carboplatin(CBP) was more effective than current chemotherapeutic combinations used to treat retinoblastoma in an orthotopic xenograft model. However, systemic coadministration of these agents is not ideal, because both agents cause dose-limiting myelosuppression in children. To overcome the toxicity associated with systemic TPT and CBP, the authors explored subconjunctival delivery of TPT or CBP in an orthotopic xenograft model and in a geneticmouse model of retinoblastoma ( ). The effects of combined subconjunctival CBP(CBPsubcon) and systemic TPT (TPTsyst) were compared with the effects of combined TPTsubcon and CBPsyst.at clinically relevant dosages. Pharmacokinetic and tumor-response studies, including analyses of ocular and hematopoietic toxicity, revealed that BPsubcon/TPTsyst was more effective and had fewer side effects than TPTsubcon/CBPsyst. For the first time, retinoblastoma was ablated and long-term vision was preserved in a mouse model by using a clinically relevant chemotherapy regimen. These results eventually may be translated into aclinical trial for children with this debilitating cancer.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CARBOPLATIN
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RETINOBLASTOMA
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TOPOTECAN
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TRANSLATIONAL RESEARCH
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-23T12:34:36Z
dc.journal.volume
117
dc.journal.number
2
dc.journal.pagination
421-434
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Nemeth, Katie M.. St. Jude Children's Research Hospital; Estados Unidos
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Fil: Federico, Sara. St. Jude Children's Research Hospital; Estados Unidos
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Fil: Carcaboso, Angel M.. St. Jude Children's Research Hospital; Estados Unidos
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Fil: Shen, Ying. St. Jude Children's Research Hospital; Estados Unidos
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Fil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Zhang, Jiakun. St. Jude Children's Research Hospital; Estados Unidos
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Fil: Egorin, Merrill. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unidos
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Fil: Stewart, Clinton. St. Jude Children's Research Hospital; Estados Unidos
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Fil: Dyer, Michael A.. St. Jude Children's Research Hospital; Estados Unidos
dc.journal.title
Cancer
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.25574
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cncr.25574
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