Artículo
Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma
Nemeth, Katie M.; Federico, Sara; Carcaboso, Angel M.; Shen, Ying; Schaiquevich, Paula Susana
; Zhang, Jiakun; Egorin, Merrill; Stewart, Clinton; Dyer, Michael A.
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
01/2011
Editorial:
John Wiley & Sons
Revista:
Cancer
ISSN:
0008-543X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The authors demonstrated previously that the combination of topotecan (TPT) and carboplatin(CBP) was more effective than current chemotherapeutic combinations used to treat retinoblastoma in an orthotopic xenograft model. However, systemic coadministration of these agents is not ideal, because both agents cause dose-limiting myelosuppression in children. To overcome the toxicity associated with systemic TPT and CBP, the authors explored subconjunctival delivery of TPT or CBP in an orthotopic xenograft model and in a geneticmouse model of retinoblastoma ( ). The effects of combined subconjunctival CBP(CBPsubcon) and systemic TPT (TPTsyst) were compared with the effects of combined TPTsubcon and CBPsyst.at clinically relevant dosages. Pharmacokinetic and tumor-response studies, including analyses of ocular and hematopoietic toxicity, revealed that BPsubcon/TPTsyst was more effective and had fewer side effects than TPTsubcon/CBPsyst. For the first time, retinoblastoma was ablated and long-term vision was preserved in a mouse model by using a clinically relevant chemotherapy regimen. These results eventually may be translated into aclinical trial for children with this debilitating cancer.
Palabras clave:
CARBOPLATIN
,
RETINOBLASTOMA
,
TOPOTECAN
,
TRANSLATIONAL RESEARCH
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Identificadores
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Nemeth, Katie M.; Federico, Sara; Carcaboso, Angel M.; Shen, Ying; Schaiquevich, Paula Susana; et al.; Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma; John Wiley & Sons; Cancer; 117; 2; 1-2011; 421-434
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