Artículo
Progression of autosomic dominant polycystic kidney disease: Influence of endothelial NO synthase (ecNOS) and renin angiotensin system gene polymorphisms
Azurmendi, Pablo Javier
; Fraga, Adriana Raquel
; Muchnik, Carolina; Farias, Maria Dos Ramos; Galan, Felicita; Guerra, Danisa; O'Flaherty, Martin; Arrizurieta, Elvira
; Martin, Rodolfo Santiago
Fecha de publicación:
12/2004
Editorial:
Medicina (Buenos Aires)
Revista:
Medicina (Buenos Aires)
ISSN:
0025-7680
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Glomerular filtration rate decline (GFRd) is variable in autosomic dominant polycystic kidney disease (ADPKD). In 88 ADPKD patients, GFRd was assessed by 1/S(Cr) and compared with the association to AT1A1166C (AT1R), AGTM235T (angiotensinogen) and ecNOSGlu298Asp (NO endothelial synthase) polymorphisms. Age at S(Cr) values of 2 and 6 mg/dl were assumed as beginning of progressive phase (A2) and end-stage-renal disease (A6), respectively. Polymorphisms were studied by PCR-RFLP. The group as a whole showed GFRd (ml/min/year) of 6.9+/-0.5; A2 and A6 of 48.9+/-1.3 and 55.0+/-1.4 years and mean arterial pressure of 111.2+/-1.2 mmHg. When A6 was considered, two populations were defined (< or = and > 55 years). In < or = 55 (assumed as PKD1 phenotype) (n=42), A2 and A6 of the AT1 1166CC genotype were 36.0+/-1.2 and 41.4+/-0.9 years vs AA-AC (42.8+/-1.0 and 47.5+/-0.8, p<0.001). A2 and A6 of the ecNOS298Asp/Asp genotype were 34.8+/-1.5 and 41.1+/-0.6 years vs. Glu/Glu-Glu/Asp (42.4+/-0.9 and 47.1+/-0.8, p<0.02). In AGT235TT genotype, GFRd was 12.4+/-2.2 ml/min/year vs MM-MT (7.9+/-0.7, p<0.03). This difference was also observed when all ADPKD patients were considered (TT: 11.02+/-1.5 vs. MM-MT: 6.44+/-0.5 ml/ min/year, p<0.003). AT1 1166CC and ecNOS 298Asp/Asp are associated with earlier A2 and A6 whereas AGT 235TT induce twofold increase in GFRd, suggesting that RAS and ecNOS are involved in ADPKD progression.
Palabras clave:
endothelial
,
ecNOS
,
renin angiotensin
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Identificadores
Colecciones
Articulos(IDIM)
Articulos de INST.DE INVEST.MEDICAS
Articulos de INST.DE INVEST.MEDICAS
Citación
Azurmendi, Pablo Javier; Fraga, Adriana Raquel; Muchnik, Carolina; Farias, Maria Dos Ramos; Galan, Felicita; et al.; Progression of autosomic dominant polycystic kidney disease: Influence of endothelial NO synthase (ecNOS) and renin angiotensin system gene polymorphisms; Medicina (Buenos Aires); Medicina (Buenos Aires); 64; 2; 12-2004; 139-142
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