Mostrar el registro sencillo del ítem
dc.contributor.author
Juritz, Ezequiel
dc.contributor.author
Fernández Alberti, Sebastián
dc.contributor.author
Parisi, Gustavo Daniel
dc.date.available
2023-03-20T17:37:55Z
dc.date.issued
2010-11
dc.identifier.citation
Juritz, Ezequiel; Fernández Alberti, Sebastián; Parisi, Gustavo Daniel; PCDB: A database of protein conformational diversity; Oxford University Press; Nucleic Acids Research; 39; 11-2010; 1-5
dc.identifier.issn
1362-4962
dc.identifier.uri
http://hdl.handle.net/11336/191053
dc.description.abstract
PCDB (http://www.pcdb.unq.edu.ar) is a database of protein conformational diversity. For each protein,the database contains the redundant compilation of all the corresponding crystallographic structures obtained under different conditions. These structures could be considered as different instances of protein dynamism. As a measure of the conformational diversity we use the maximum RMSD obtained comparing the structures deposited for each domain. The redundant structures were extracted following CATH structural classification and cross linked with additional information. In this way it is possible to relate a given amount of conformational diversity with different levels of information,such as protein function,presence of ligands and mutations,structural classification,active site information and organism taxonomy among others. Currently the database contains 7989 domains with a total of 36581 structures from 4171 different proteins. The maximum RMSD registered is 26.7A and the average of different structures per domain is 4.5.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
conformational diversity
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
PCDB: A database of protein conformational diversity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-03-20T14:48:49Z
dc.journal.volume
39
dc.journal.pagination
1-5
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Juritz, Ezequiel. Universidad Nacional de Quilmes. Centro de Est.e Investigación. Prog.simulación de Proc.moleculares de Relevancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fernández Alberti, Sebastián. Universidad Nacional de Quilmes. Centro de Est.e Investigación. Prog.simulación de Proc.moleculares de Relevancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Centro de Est.e Investigación. Prog.simulación de Proc.moleculares de Relevancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Nucleic Acids Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://nar.oxfordjournals.org/content/early/2010/11/19/nar.gkq1181
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/nar/gkq1181
Archivos asociados