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dc.contributor.author
Lujan, Hugo Daniel  
dc.date.available
2023-03-13T17:16:59Z  
dc.date.issued
2011-04  
dc.identifier.citation
Lujan, Hugo Daniel; Mechanisms of adaptation in the intestinal parasite Giardia lamblia; Journal of the Serbian Chemical Society; Essays In Biochemistry; 51; 1; 4-2011; 177-191  
dc.identifier.issn
0071-1365  
dc.identifier.uri
http://hdl.handle.net/11336/190366  
dc.description.abstract
Giardia lamblia, a parasite of humans, is a major source of waterborne diarrhoeal disease. Giardia is also an excellent system to study basic biochemical processes because it is a single-celled eukaryote with a small genome and its entire life cycle can be replicated in vitro. Giardia trophozoites undergo fundamental changes to survive outside the intestine of their host by differentiating into infective cysts. Encystation entails the synthesis, processing, transport, secretion and extracellular assembly of cyst wall components. To survive within the intestine, Giardia undergoes antigenic variation, a process by which the parasite continuously switches its major surface molecules, allowing the parasite to evade the host's immune response and produce chronic and recurrent infections. The objective of the present chapter is to provide a better understanding of the molecular mechanisms involved in adaptation and differentiation in Giardia, with a particular focus on the process of encystation and antigenic variation of this interesting micro-organism.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Journal of the Serbian Chemical Society  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Antigenic variation  
dc.subject
Protein  
dc.subject
Adaptation  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Mechanisms of adaptation in the intestinal parasite Giardia lamblia  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-03-10T14:32:51Z  
dc.identifier.eissn
1744-1358  
dc.journal.volume
51  
dc.journal.number
1  
dc.journal.pagination
177-191  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Lujan, Hugo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina  
dc.journal.title
Essays In Biochemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1042/bse0510177  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/essaysbiochem/article-abstract/doi/10.1042/bse0510177/78305/Mechanisms-of-adaptation-in-the-intestinal?redirectedFrom=fulltext